Kevin M. Wright

TL;DR: Ecological selection on an adaptive allele causes a tightly linked hybrid incompatibility factor to rapidly hitchhike to high frequency in a population of the wildflower Mimulus guttatus.

TL;DR: The subterranean-dwelling naked mole-rat (NM-R) exhibits prolonged life span relative to its body size, is unusually cancer resistant, and manifests few physiological or molecular changes with advancing age, challenging current understanding of mammalian immunity.

TL;DR: Predicting which enzymes will be preferentially involved in adaptive evolution thus requires an evolutionary theory of flux control, which generates two main predictions for pathways in which reactions are moderately to highly irreversible: flux control will evolve to be highly unequal among enzymes in a pathway and upstream enzymes evolve a greater control coefficient then those downstream.

TL;DR: This work has identified a minimal repression domain within giant that encompasses residues 89-205, including an evolutionarily conserved region bearing a putative CtBP binding motif, and demonstrates that giant can repress both via CtBP-dependent andCtBP-independent pathways, and that promoter context is critical for determining giant-CtBP functional interaction.