Kevin J. Tracey
The Feinstein Institute for Medical Research
609 Papers
4.5K Citations
Kevin J. Tracey is an academic researcher from The Feinstein Institute for Medical Research. The author has contributed to research in topics: Inflammation & Medicine. The author has an hindex of 138, co-authored 561 publications. Previous affiliations of Kevin J. Tracey include Memorial Sloan Kettering Cancer Center & Hofstra University.
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Papers
Brain Region-Specific Alterations in the Gene Expression of Cytokines, Immune Cell Markers and Cholinergic System Components during Peripheral Endotoxin-Induced Inflammation
Harold A. Silverman,Harold A. Silverman,Meghan Dancho,Angelique Regnier-Golanov,Mansoor Nasim,Mahendar Ochani,Peder S. Olofsson,Mohamed Ahmed,Mohamed Ahmed,Edmund J. Miller,Edmund J. Miller,Sangeeta S. Chavan,Eugene V. Golanov,Christine N. Metz,Christine N. Metz,Kevin J. Tracey,Kevin J. Tracey,Valentin A. Pavlov,Valentin A. Pavlov +18 more
TL;DR: A previously unrecognized regional specificity in brain immunoregulatory and cholinergic system gene expression is revealed in the context of peripheral inflammation and is of interest for designing future antiinflammatory approaches.
Patent
Treating inflammatory disorders by electrical vagus nerve stimulation
Jared M. Huston,Kevin J. Tracey +1 more
- 22 Jun 2005
TL;DR: A method and an apparatus for treating a patient suffering from, or at risk for, a condition mediated by the inflammatory cytokine cascade, by electrically stimulating vagus nerve activity in an amount sufficient to inhibit the inflammatory cascade is described in this paper.
104
Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers.
Shu Zhu,Shu Zhu,Mala Ashok,Mala Ashok,Jianhua Li,Wei Li,Wei Li,Huan Yang,Ping Wang,Kevin J. Tracey,Andrew E. Sama,Haichao Wang,Haichao Wang +12 more
TL;DR: In vitro, spermine effectively inhibited HMGB1-induced release of the above surrogate markers in peritoneal macrophages and confers protection against lethal sepsis partly by attenuating sepsi- and HMGB 1-induced inflammatory responses.
99
It takes nerve to dampen inflammation.
TL;DR: Stimulation of the vagus nerve via the α7 nicotinic acetylcholine receptor can dampen macrophage function and this anti-inflammatory pathway seems to signal through the Jak2-STAT3 pathway.
99
Identification of a brainstem locus that inhibits tumor necrosis factor.
Adam M. Kressel,Tea Tsaava,Yaakov A. Levine,Eric H. Chang,Meghan E. Addorisio,Qing Chang,Barry J Burbach,Daniela Carnevale,Daniela Carnevale,Giuseppe Lembo,Giuseppe Lembo,Anthony M. Zador,Ulf Andersson,Valentin A. Pavlov,Sangeeta S. Chavan,Kevin J. Tracey +15 more
TL;DR: Optogenetics and functional mapping reveal cholinergic neurons in the DMN, which project to the celiac-superior mesenteric ganglia, significantly increase splenic nerve activity and inhibit TNF production, revealing a role for brainstem coordination of immunity.