Kevin J. Tracey
The Feinstein Institute for Medical Research
609 Papers
4.5K Citations
Kevin J. Tracey is an academic researcher from The Feinstein Institute for Medical Research. The author has contributed to research in topics: Inflammation & Medicine. The author has an hindex of 138, co-authored 561 publications. Previous affiliations of Kevin J. Tracey include Memorial Sloan Kettering Cancer Center & Hofstra University.
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Papers
Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock
Michael Ombrellino,Haichao Wang,Michael S Ajemian,Akram Talhouk,Larry A. Scher,Steven G. Friedman,Kevin J. Tracey +6 more
TL;DR: Serum concentrations of high-mobility-group protein 1 (HMG1) were increased during an episode of haemorrhagic shock in a patient who had undergone repair of an abdominal aortic aneurysm, suggesting HMG1 may be involved in the pathogenesis of human haemOrrhagic Shock.
Development and characterization of a chronic implant mouse model for vagus nerve stimulation.
Ibrahim T. Mughrabi,Jordan Hickman,Naveen Jayaprakash,Dane Thompson,Umair Ahmed,Eleni S. Papadoyannis,Yao-Chuan Chang,Adam Abbas,Timir Datta-Chaudhuri,Eric H. Chang,Theodoros P. Zanos,Sunhee C Lee,Robert C. Froemke,Kevin J. Tracey,Cristin G. Welle,Yousef Al-Abed,Stavros Zanos +16 more
TL;DR: In this article, a scalable model for long-term VNS in mice developed and validated in four research laboratories was described, where significant heart rate responses for at least 4 weeks in 60-90% of animals were observed.
•Journal Article
Famotidine use and quantitativesymptom tracking for COVID-19 in nonhospitalizedpatients: A case series
Tobias Janowitz,Eva C. Gablenz,David J. Pattinson,Timothy C. Wang,Joseph Conigliaro,Kevin J. Tracey,David A. Tuveson +6 more
TL;DR: The results of this case series suggest that high-dose oral famotidine is well tolerated and associated with improved patient-reported outcomes in non-hospitalised patients with COVID-19.
MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
Jürgen Bernhagen,Thierry Calandra,Robert A. Mitchell,S. B. Martin,Kevin J. Tracey,Wolfgang Voelter,Kirk R. Manogue,A. Cerami,Richard Bucala +8 more
TL;DR: Macrophage migration inhibitory factor (MIF) is identified as a major secreted protein released by anterior pituitary cells in response to LPS stimulation, and it is concluded that MIF plays a central role in the toxic response to endotoxaemia and possibly septic shock.
Novel strategies for targeting innate immune responses to influenza
Kari Ann Shirey,W.Y.C. Lai,Mira C. Patel,Lioubov M. Pletneva,C Pang,Evelyn A. Kurt-Jones,Michael M. Lipsky,Thierry Roger,Thierry Calandra,Kevin J. Tracey,Yousef Al-Abed,Andrew G. Bowie,Alessio Fasano,C A Dinarello,Fabian Gusovsky,Jorge C. G. Blanco,Stefanie N. Vogel +16 more
TL;DR: The data support the potential of a host-targeted therapeutic approach to influenza infection and determine that Eritoran blocks high-mobility group B1 (HMGB1)-mediated, TLR4-dependent signaling in vitro and circulating HMGB1 in vivo, and an HMGB 1 inhibitor protects against PR8.