Ketty Kessler
Institute of Cancer Research
13 Papers
5 Citations
Ketty Kessler is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Biology & In vivo. The author has an hindex of 5, co-authored 9 publications. Previous affiliations of Ketty Kessler include Paris Diderot University.
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Papers
Angiogenesis and remodelling in human thoracic aortic aneurysms.
Ketty Kessler,Luciano de Figueiredo Borges,Benoît Ho-Tin-Noé,Guillaume Jondeau,Jean-Baptiste Michel,Jean-Baptiste Michel,Roger Vranckx +6 more
TL;DR: Although the initiating mechanisms of neo-angiogenesis in TAA and the potential aetiology-related differences remain to be determined, the results suggest that neo-Angiogenesis could participate in T AA wall remodelling and weakening through deposition of blood-borne zymogens.
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Drug screening linked to molecular profiling identifies novel dependencies in patient-derived primary cultures of paediatric high grade glioma and DIPG
Diana Carvalho,Sara Temelso,Alan Mackay,Helen N. Pemberton,Rebecca Rogers,Ketty Kessler,Elisa Izquierdo,Lynn Bjerke,Janat Fazal Salom,Matthew Clarke,Yura Grabovska,Anna Burford,Nagore G. Olaciregui,Jessica K.R. Boult,Valeria Molinari,Mariama Fofana,Paula Proszek,Elisabet F Potente,Kathryn R. Taylor,Kathryn R. Taylor,Christopher Chandler,Bassel Zebian,Ranj Bhangoo,Andrew J. Martin,Bassam Dabbous,Simon R. Stapleton,Samantha Hettige,Lynley V. Marshall,Lynley V. Marshall,Fernando Carceller,Fernando Carceller,Henry Mandeville,Sucheta Vaidya,Safa Al-Sarraj,Leslie R. Bridges,Robert Johnston,Jane Cryan,Michael Farrell,Darach Crimmins,John Caird,Jane Pears,Giulia Pericoli,Evelina Miele,Angela Mastronuzzi,Franco Locatelli,Andrea Carai,Simon P. Robinson,Mike Hubank,Michelle Monje,Andrew S. Moore,Andrew S. Moore,Timothy E.G. Hassall,Timothy E.G. Hassall,Timothy E.G. Hassall,Angel M. Carcaboso,Christopher J. Lord,Mara Vinci,Chris Jones +57 more
TL;DR: In this paper, the authors present 17 primary cell cultures derived from patients in London, Dublin and Belfast, and together with cultures established or shared from Barcelona, Brisbane, Rome and Stanford, assembled a panel of 52 models under 2D (laminin matrix) and/or 3D (neurospheres) conditions.
5
Transforming growth factor-β1 SMAD effectors and medial cell number in ascending aorta diseases
Rosemeire Aparecida-Silva,Luciano de Figueiredo Borges,Ketty Kessler,Ricardo Ribeiro Dias,Luiz Felipe P. Moreira,Jorge Kalil,Paulo Sampaio Gutierrez +6 more
TL;DR: In ascending aortic aneurysms and dissections, there is an increase in SMAD4, implicated in extracellular matrix production, possibly as an attempt to compensate for extrace cellular matrix deficiency.
3
IMG-09. Characterisation of a panel ofin vivo models of paediatric-type diffuse high-grade glioma (PDHGG) using magnetic resonance imaging
Jessica K.R. Boult,Diana Carvalho,Ketty Kessler,Maria Vinci,Elisabet Fernandez,Lynn Bjerke,Mariama Fofana,Valeria Molinari,Angel M. Carcaboso,Chris Jones,Simon P. Robinson +10 more
TL;DR: The study highlights the potential of non-invasive MRI to accurately evaluate the efficacy of novel therapeutics in these PDHGG models.
HGG-42. Evolutionary selection of key oncogenic alterations in patient-derived models of paediatric diffuse high grade glioma (PDHGG) subtypesin vitro andin vivo
Alan Mackay,Sara Temelso,Diana Carvalho,Ketty Kessler,Jessica K.R. Boult,Elisa Izquierdo,Rita Pereira,E. F. Potente,Anna Burford,Valeria Molinari,Lynn Bjerke,Yura Grabovska,Rebecca Rogers,Shauna Crampsie,Molina Das,Simon P. Robinson,Matthew Clarke,Chris Jones +17 more
TL;DR: Multi-region sequencing of diffusely-infiltrating tumours showed selection for alterations such as PIK3CA/NF1 at distant sites, with evidence for convergent evolution of subclonal mutations, as in human tumours.