Effects of gender and sex steroids on the immune response

Six autoimmune murine models (MRL/l, MRL/n, NZB, NZB/NZW, PN, C57BL/6J-lpr/lpr) were compared with normal control C57BL/6J and DBA/2 mice to determine if spontaneous autoimmune disease was associated with evidence of Sjogren's syndrome. Schirmer tests documented dry eyes in NZB/NZW and PN mice; other autoimmune strains and controls had normal tear formation. All autoimmune mice had conjunctivitis, but this abnormality was most severe in the PN strain. Ninety-eight percent of MRL/1 and MRL/n mice had mononuclear cell infiltrates in lacrimal glands, and salivary glands were involved to a lesser degree. New Zealand mice and PN mice had smaller gland lesions. The extensive gland destruction in MRL/l and MRL/n mice suggested that these substrains merit further studies as animal models of Sjogren's syndrome.

Sjögren's syndrome in MRL/l and MRL/n mice.

Recent advances in the study of Sjogren's syndrome include detection of antisalivary duct antibody (ASDA) in patients' sera, development of sensitive techniques to evaluate salivary glandu...

Sjögren's Syndrome—Newer Aspects of Research, Diagnosis, and Therapy

Virus-like structures in sjögren's syndrome

The pathogenesis of autoimmunity in New Zealand mice

A laboratory model for Sjögren's syndrome.

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A laboratory model for Sjögren's syndrome.