Kensuke Iwasa
Saitama Medical University
16 Papers
1 Citations
Kensuke Iwasa is an academic researcher from Saitama Medical University. The author has contributed to research in topics: Multiple sclerosis & Neuroinflammation. The author has an hindex of 5, co-authored 10 publications.
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Papers
Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease.
Shinji Yamamoto,Kota Yamashina,Masaki Ishikawa,Mari Gotoh,Sosuke Yagishita,Kensuke Iwasa,Kei Maruyama,Kimiko Murakami-Murofushi,Keisuke Yoshikawa +8 more
TL;DR: It is demonstrated that 2ccPA protected oligodendrocytes via suppression of the mitochondrial apoptosis pathway and may be a promising compound for the development of new drugs to treat demyelinating disease and ameliorate the symptoms of multiple sclerosis.
Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model
Kensuke Iwasa,Shinji Yamamoto,M. Takahashi,Seiya Suzuki,Sosuke Yagishita,Takeo Awaji,Kei Maruyama,Keisuke Yoshikawa +7 more
TL;DR: During cuprizone-induced demyelination, PGF2α/FP receptor signaling contributes to glial activation, neuroinflammation, and demyELination, resulting in motor dysfunction, suggesting that FP receptor inhibition may be a useful symptomatic treatment in multiple sclerosis.
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Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1.
Shinji Yamamoto,Chiaki Sakemoto,Kensuke Iwasa,Kei Maruyama,Kuniyoshi Shimizu,Keisuke Yoshikawa +5 more
TL;DR: Oral administration of ursolic acid effectively suppressed cuprizone-induced demyelination and motor dysfunction via the enhancement of IGF-1 levels in the demYelinating lesions, suggesting that UA might be therapeutically useful for demyElination in MS.
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Excitotoxicity-induced prostaglandin D2 production induces sustained microglial activation and delayed neuronal death
TL;DR: Findings suggest that excitotoxic delayed neuronal death is mediated through microglia activated by PGD2, and thatPGD2 enhanced microglial activation, which may be involved in the delayed neurons death in the hippocampus.
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Quantitative determination of cyclic phosphatidic acid and its carba analog in mouse organs and plasma using LC-MS/MS.
Yoshibumi Shimizu,Masaki Ishikawa,Mari Gotoh,Keiko Fukasawa,Shinji Yamamoto,Kensuke Iwasa,Keisuke Yoshikawa,Kimiko Murakami-Murofushi +7 more
TL;DR: A liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based quantification method for the simultaneous detection of cPA species having various fatty acids as well as 2-carba-cPA, a chemically synthesized analog of c PA, revealed to be significantly reduced in the brains of cuprizone-treated mice, a model of multiple sclerosis.
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