Kenneth H. Roux

TL;DR: The extraordinary configuration of this antibody provides an extended surface, with newly described binding sites, for multivalent interaction with a conserved cluster of oligomannose type sugars on the surface of gp120, finding a previously unappreciated mechanism for high-affinity recognition of carbohydrate or other repeating epitopes on cell or microbial surfaces.

TL;DR: Reconciling available atomic structures with the three-dimensional whole spike density map yields insights into the orientation of Env spike structural elements and possible structural bases of their functions.

TL;DR: A smaller promiscuous biotin ligase for proximity biotinylation called BioID2 enables more-selective targeting of fusion proteins, requires less biotin supplementation, exhibits enhanced labeling of proximate proteins, and demonstrates the use of a flexible linker to modulate the biotin-labeling radius.

TL;DR: The characteristics of TD PCR are investigated that serve to minimize the need to optimize annealing temperature or buffer conditions and yet produce single strong target amplicons and it is demonstrated that priming initiates above the optimum annealed temperature.