Kenneth B. Adler
North Carolina State University
198 Papers
1.7K Citations
Kenneth B. Adler is an academic researcher from North Carolina State University. The author has contributed to research in topics: Mucin & MARCKS. The author has an hindex of 47, co-authored 195 publications. Previous affiliations of Kenneth B. Adler include Georgetown University & North Carolina State University College of Veterinary Medicine.
Chat about Author
Papers
A common MUC5B promoter polymorphism and pulmonary fibrosis
Max A. Seibold,Anastasia L. Wise,Marcy C. Speer,Mark P. Steele,Kevin K. Brown,James E. Loyd,Tasha E. Fingerlin,Weiming Zhang,Gunnar Gudmundsson,Steve D. Groshong,Christopher M. Evans,Stavros Garantziotis,Kenneth B. Adler,Burton F. Dickey,Roland M. du Bois,Ivana V. Yang,Aretha Herron,Dolly Kervitsky,Janet Talbert,Cheryl Markin,Joungjoa Park,Anne L. Crews,Susan Slifer,Scott S. Auerbach,Michelle G. Roy,Jia Lin,Corinne E. Hennessy,Marvin I. Schwarz,David A. Schwartz +28 more
TL;DR: The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot.
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
Phuong-Uyen Dinh,Dipti Paudel,Hayden N. Brochu,Kristen D. Popowski,M. Cyndell Gracieux,Jhon Cores,Jhon Cores,Ke Huang,M. Taylor Hensley,Erin Harrell,Adam C. Vandergriff,Arianna George,Raina T. Barrio,Shiqi Hu,Shiqi Hu,Tyler A. Allen,Kevin Blackburn,Thomas G. Caranasos,Xinxia Peng,Lauren V. Schnabel,Kenneth B. Adler,Leonard J. Lobo,Michael B. Goshe,Ke Cheng,Ke Cheng +24 more
TL;DR: It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells.
A biphasic chamber system for maintaining polarity of differentiation of culture respiratory tract epithelial cells
TL;DR: The results suggest that, at least for guinea pigs, the combination of feeding methods provided by the Whitcutt chamber can be used to achieve differentiated cultures of tracheal epithelial cells with a polarity of differentiation that is similar to that observed in intact airways in vivo.
259
MARCKS Protein Is a Key Molecule Regulating Mucin Secretion by Human Airway Epithelial Cells in Vitro
TL;DR: Several novel intracellular targets for pharmacological intervention in disorders involving aberrant secretion of respiratory mucin are suggested and may relate to other lesions involving exocytosis of membrane-bound granules in various cells and tissues.
201
A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma
Monique Singer,Linda D. Martin,B. Boris Vargaftig,Joungjoa Park,Achim D. Gruber,Yuehua Li,Kenneth B. Adler +6 more
TL;DR: It is shown that the intratracheal instillation of this peptide blocks mucus hypersecretion in a mouse model of asthma, and a pivotal role for MARCKS protein, specifically its N-terminal region, in modulating this secretory process in mammalian airways is supported.
186