Kennedy R. Lees
University of Glasgow
467 Papers
3.9K Citations
Kennedy R. Lees is an academic researcher from University of Glasgow. The author has contributed to research in topics: Stroke & Medicine. The author has an hindex of 86, co-authored 455 publications. Previous affiliations of Kennedy R. Lees include Ludwig Maximilian University of Munich & Cedars-Sinai Medical Center.
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Papers
Continuing or Temporarily Stopping Prestroke Antihypertensive Medication in Acute Stroke: An Individual Patient Data Meta-Analysis
Lisa J Woodhouse,Lisa Manning,John F. Potter,Eivind Berge,Nikola Sprigg,Joanna M. Wardlaw,Kennedy R. Lees,Philip M.W. Bath,Thompson G. Robinson +8 more
TL;DR: In this article, an individual patient data meta-analysis from randomized controlled trials was undertaken to determine the effect of continuation versus temporarily stopping preexisting antihypertensive medication in acute stroke.
Selfotel in acute ischemic stroke : Possible neurotoxic effects of an NMDA antagonist
Stephen M. Davis,Kennedy R. Lees,Gregory W. Albers,Hans-Christoph Diener,Sabri Markabi,Goeril Karlsson,John W. Norris +6 more
TL;DR: Selfotel was not an effective treatment for acute ischemic stroke and a trend toward increased mortality, particularly within the first 30 days and in patients with severe stroke, suggests that the drug might have a neurotoxic effect in brain ischemia.
The clinical pharmacology of ace inhibitors: evidence for clinically relevant differences?
TL;DR: Significant differences among ACE inhibitors include pharmacokinetic and pharmacodynamic factors, and the route of elimination are examples of possible differences.
NXY-059 for acute ischemic stroke
Kennedy R. Lees,Justin A. Zivin,Tim Ashwood,Antonio Dávalos,Stephen M. Davis,Hans-Christoph Diener,James C. Grotta,Patrick D. Lyden,Ashfaq Shuaib,Hans-Göran Hårdemark,Warren W. Wasiewski +10 more
TL;DR: The administration of NXY-059 within six hours after the onset of acute ischemic stroke significantly improved the primary outcome (reduced disability at 90 days), but it did not significantly improve other outcome measures, including neurologic functioning as measured by the NIHSS score.
Mismatch-Based Delayed Thrombolysis A Meta-Analysis
Nishant K. Mishra,Gregory W. Albers,Stephen M. Davis,Geoffrey A. Donnan,Anthony J. Furlan,Werner Hacke,Kennedy R. Lees +6 more
TL;DR: Delayed thrombolysis amongst patients selected according to mismatch imaging is associated with increased reperfusion/recanalization, but delayed treatment, even according to mismatch selection, cannot be recommended as part of routine care.