Kennedy R. Lees
University of Glasgow
467 Papers
3.9K Citations
Kennedy R. Lees is an academic researcher from University of Glasgow. The author has contributed to research in topics: Stroke & Medicine. The author has an hindex of 86, co-authored 455 publications. Previous affiliations of Kennedy R. Lees include Ludwig Maximilian University of Munich & Cedars-Sinai Medical Center.
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Papers
Seven-Day NIHSS Is a Sensitive Outcome Measure for Exploratory Clinical Trials in Acute Stroke Evidence From the Virtual International Stroke Trials Archive
TL;DR: Seven-day NIHSS score appears a sensitive end point that should be validated in randomized trial datasets for use in exploratory stroke trials.
Doppler emboli signals vary according to stroke subtype.
TL;DR: Emboli signals are common in patients with acute stroke, with the notable exception of lacunar stroke, which is consistent with the small vessel etiology for the latter group and provides support for the relevance of Doppler emboli signal detection in thromboembolic cerebrovascular disease.
Central adjudication of serious adverse events did not affect trial’s safety results: Data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial
Peter J. Godolphin,Alan A Montgomery,Lisa J Woodhouse,Dániel Bereczki,Eivind Berge,Ronan Collins,Exuperio Díez-Tejedor,John Gommans,Kennedy R. Lees,Şerefnur Öztürk,Stephen J. Phillips,Stuart J. Pocock,Kameshwar Prasad,Szabolcs Szatmári,Yongjun Wang,Philip M.W. Bath,Nikola Sprigg +16 more
TL;DR: In a large trial, with many SAEs reported, central adjudication of these events did not affect trial conclusions, suggesting that adjudication in a clinical trial where the intervention already has a well-established safety profile may not be necessary.
Machine Learning–Based Identification of Target Groups for Thrombectomy in Acute Stroke
Fanny Quandt,Fabian Flottmann,Vince I. Madai,Anna Alegiani,Clemens Küpper,Lars Kellert,Adam Hilbert,Dietmar Frey,Thomas Liebig,Mayank Goyal,Jeffrey L. Saver,Christian Gerloff,Götz Thomalla,Steffen Tiedt,Jörg Berrouschot,Albrecht Bormann,Georg Bohner,Christian H. Nolte,Eberhard Siebert,Sarah Zweynert,Franziska Dorn,Gabor C. Petzold,Fee Keil,Waltraud Pfeilschifter,Gerhard F. Hamann,M. Braun,Bernd Eckert,Julia Röther,Jens Fiehler,Goetz Thomalla,Christoffer Kraemer,Klaus Gröschel,Timo Uphaus,Scott Tiedt,Christoph G. Trumm,Tobias Boeckh-Behrens,Silke Wunderlich,A. Ludolph,Martina Petersen,Florian Stögbauer,Ulrike Ernemann,Serena Poli,Pooja Khatri,Martin Bendszuz,Serge Bracard,Joseph P. Broderick,B Campbell,Alfonso Ciccone,Antoni Dávalos,SM Davis,A. Demchuk,Hans-Christoph Diener,Diederik W.J. Dippel,Geoffrey A. Donnan,Xavier Ducrocq,David Fiorella,Gary A. Ford,M. Goyal,Werner Hacke,Michelle Hill,Reza Jahan,Edward C. Jauch,Tudor G Jovin,Chelsea S. Kidwell,Kennedy R. Lees,David S Liebeskind,Charles B. L. M. Majoie,Sheila Cristina Ouriques Martins,Peter Mitchell,J Mocco,K. W. Muir,Raul G Nogueira,J. L. Saver,W. Schonewille,Adnan H. Siddiqui,Thomas A. Tomsick,Aquilla S Turk,Wim H. van Zwam,Philip White,Sohei Yoshimura,Osama O. Zaidat +80 more
TL;DR: In this paper , the importance of reperfusion level on functional outcome prediction using machine learning in patients with LVO stroke treated with endovascular thrombectomy in clinical practice and in patients treated with EVT or best medical management from randomized controlled trials (RCTs).
•Journal Article
Indirect assessment of tissue angiotensin II converting enzyme inhibition in vivo in man.
TL;DR: The pharmacokinetics of long-acting angiotensin converting enzyme (ACE) inhibitors show features which are consistent with saturable binding of the drugs to ACE, and the extent and affinity of ACE inhibitor binding to tissue ACE may be estimated from appropriate analysis of pharmacokinetic data in man.