Kennedy R. Lees
University of Glasgow
467 Papers
3.9K Citations
Kennedy R. Lees is an academic researcher from University of Glasgow. The author has contributed to research in topics: Stroke & Medicine. The author has an hindex of 86, co-authored 455 publications. Previous affiliations of Kennedy R. Lees include Ludwig Maximilian University of Munich & Cedars-Sinai Medical Center.
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Papers
Effect of Perindopril on Cerebral and Renal Perfusion on Normotensives in Mild Early Ischaemic Stroke: A Randomized Controlled Trial
TL;DR: Antihypertensive therapy with perindopril may be introduced in the first week after mild ischaemic stroke in normotensive patients without affecting global or regional CBF or affecting GFR.
Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell’Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials
Azmil H. Abdul-Rahim,Ana Cristina Perez,Rachael L. Fulton,Pardeep S. Jhund,Roberto Latini,Gianni Tognoni,John Wikstrand,John Kjekshus,Gregory Y.H. Lip,Aldo P. Maggioni,Luigi Tavazzi,Kennedy R. Lees,John J.V. McMurray +12 more
TL;DR: A small number of demographic and clinical variables identified a subset of patients who have heart failure without AF at a high risk of stroke and found that patients in the upper third of risk had a rate of stroke that approximated the risk in patients with AF.
Outcome after stroke thrombolysis in patients >80 years treated within 3 hours vs >3-4.5 hours.
Niaz Ahmed,Kennedy R. Lees,Peter A. Ringleb,Christopher F. Bladin,David Collas,Danilo Toni,Gary A. Ford +6 more
TL;DR: Unselected patients >80 years of age treated with IVT after 3 hours vs earlier had a slightly higher rate of SICH and similar unadjusted functional outcome but poorer adjusted outcome, and elderly patients should not be denied IVT in the later time window.
The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial
TL;DR: Xanthine oxidase inhibition with allopurinol has previously been shown to improve cerebrovascular function, but no benefit was seen in this study and it may therefore be that previous encouraging findings will not translate into important clinical benefits.
EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke.
H. Bart van der Worp,Malcolm R. Macleod,Philip M.W. Bath,Jacques Demotes,Isabelle Durand-Zaleski,Bernd Gebhardt,Christian Gluud,Rainer Kollmar,Derk W. Krieger,Kennedy R. Lees,Carlos A. Molina,Joan Montaner,Risto O. Roine,Jesper Petersson,Dimitre Staykov,Istvan Szabo,Joanna M. Wardlaw,Stefan Schwab +17 more
TL;DR: To determine whether systemic cooling to a target body temperature between 34·0 and 35·0°C, started within six-hours of symptom onset and maintained for 24 h, improves functional outcome at three-months in patients with acute ischemic stroke.