Kennedy R. Lees
University of Glasgow
467 Papers
3.9K Citations
Kennedy R. Lees is an academic researcher from University of Glasgow. The author has contributed to research in topics: Stroke & Medicine. The author has an hindex of 86, co-authored 455 publications. Previous affiliations of Kennedy R. Lees include Ludwig Maximilian University of Munich & Cedars-Sinai Medical Center.
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Papers
Remacemide hydrochloride : A double-blind, placebo-controlled, safety and tolerability study in patients with acute ischemic stroke
A. G. Dyker,Kennedy R. Lees +1 more
TL;DR: The maximum well-tolerated dose for remacemide hydrochloride in acute stroke is 400 mg BID, and the most common adverse events considered by the investigator to be possibly treatment related were related to the central nervous system, and these events appeared to increase with dose.
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Stroke Outcome in Clinical Trial Patients Deriving From Different Countries
Myzoon Ali,Sari Atula,Philip M.W. Bath,James C. Grotta,Werner Hacke,Patrick D. Lyden,John R. Marler,Ralph L. Sacco,Kennedy R. Lees +8 more
TL;DR: Regional variations in index stroke severity, outcome, and mortality for patients enrolled in ischemic stroke clinical trials over the past 13 years that were not fully explained by case mix are identified.
IV thrombolysis in very severe and severe ischemic stroke: Results from the SITS-ISTR Registry
Michael V. Mazya,Kennedy R. Lees,David Collas,Viiu-Marika Rand,Robert Mikulik,Danilo Toni,Nils Wahlgren,Niaz Ahmed +7 more
TL;DR: The data show no excess risk of cerebral hemorrhage in patients with NIHSS score >25 compared to score 15–25, suggesting that the European contraindication to IV tissue plasminogen activator treatment at NIHSS levels >25 may be unwarranted.
Magnesium for Treatment of Acute Lacunar Stroke Syndromes: Further Analysis of the IMAGES Trial
TL;DR: The positive treatment effect of Mg in LACS cannot be ascribed to general issues of severity, time to treatment, blood pressure, or other baseline factors; equally, this finding may be due to chance.
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A Randomized, Double-Blind, Placebo-Controlled Pilot Trial of Intravenous Magnesium Sulfate in Acute Stroke
Keith W. Muir,Kennedy R. Lees +1 more
TL;DR: Magnesium ions act as endogenous vasodilators of the cerebral circulation and act pharmacologically as noncompetitive antagonists of the N-methyl-d-aspartate receptor by virt...
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