Kennedy R. Lees
University of Glasgow
467 Papers
3.9K Citations
Kennedy R. Lees is an academic researcher from University of Glasgow. The author has contributed to research in topics: Stroke & Medicine. The author has an hindex of 86, co-authored 455 publications. Previous affiliations of Kennedy R. Lees include Ludwig Maximilian University of Munich & Cedars-Sinai Medical Center.
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Papers
Glycine Antagonist (GV150526) in Acute Stroke: A Multicentre, Double-Blind Placebo-Controlled Phase II Trial
TL;DR: GV150526 was generally well tolerated in patients with a clinical diagnosis of acute stroke and formal efficacy studies were considered justified, and results probably reflect a prognostically significant baseline difference between the groups rather than the effect of GV 150526.
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Pharmacological effects of the non‐competitive NMDA antagonist CNS 1102 in normal volunteers
TL;DR: CNS 1102, a novel non-competitive NMDA antagonist, was administered as a 15 min intravenous infusion to healthy male volunteers in a double-blind, placebo-controlled, dose-ranging study and Pharmacokinetic properties are favourable for a potential neuroprotective therapy.
Thrombolytic therapy for acute stroke in the United Kingdom: experience from the safe implementation of thrombolysis in stroke (SITS) register
Kennedy R. Lees,Gary A. Ford,Keith W. Muir,Niaz Ahmed,Alexander G. Dyker,S. Atula,Lalit Kalra,Elizabeth A. Warburton,Jean-Claude Baron,D.F. Jenkinson,N.G. Wahlgren,Matthew Walters +11 more
TL;DR: Thrombolytic therapy for stroke has been implemented successfully at a small number of UK stroke centres, with patchy provision throughout the country, and the low frequency of treatment out with office hours suggests deficient infrastructure to support delivery.
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Susceptibility to Cerebral Infarction in the Stroke-Prone Spontaneously Hypertensive Rat Is Inherited as a Dominant Trait
Julie A. Gratton,Andre Sauter,Markus Rudin,Kennedy R. Lees,John H. McColl,John L. Reid,Anna F. Dominiczak,I. Mhairi Macrae +7 more
TL;DR: Outcome to MCA occlusion (MCAO) measured with MRI provides a reproducible and nonterminal quantitative phenotypic marker of stroke susceptibility in the SHRSP and indicates a dominant mode of inheritance for this phenotype.
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Lack of association between angiotensin converting enzyme gene insertion/deletion polymorphism and stroke
Shinichiro Ueda,Christopher J. Weir,G. C. Inglis,Gordon D Murray,Keith W. Muir,Kennedy R. Lees +5 more
TL;DR: The DD genotype may not be a risk factor for stroke, particularly in the normotensive population, and further study is required to test for the possibility of an increased risk of stroke in hypertensives with DD homozygotes.
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