Kennedy R. Lees
University of Glasgow
467 Papers
3.9K Citations
Kennedy R. Lees is an academic researcher from University of Glasgow. The author has contributed to research in topics: Stroke & Medicine. The author has an hindex of 86, co-authored 455 publications. Previous affiliations of Kennedy R. Lees include Ludwig Maximilian University of Munich & Cedars-Sinai Medical Center.
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Papers
Does Hemispheric Lateralization Influence Functional and Cardiovascular Outcomes After Stroke? An Analysis of Placebo-Treated Patients From Prospective Acute Stroke Trials
TL;DR: Stroke lateralization is not an important predictor of cardiac adverse events or 90-day mortality, and use of the baseline NIHSS score to predict stroke outcome must take hemispheric lateralization into account.
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Comparison of stratification and adaptive methods for treatment allocation in an acute stroke clinical trial - Arthor's reply
TL;DR: The feasibility of adaptive stratification in the context of a clinical trial of insulin to control plasma glucose level following acute stroke and the importance of the method of analysis in realizing the gain in power which may potentially be achieved by allocating treatments using stratified random blocks or adaptive stratisation is considered.
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Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage
Mark O. McCarron,Christopher J. Weir,Keith W. Muir,K. L. Hoffmann,Carmelo Graffagnino,Jar Nicoll,Kennedy R. Lees,Mark J. Alberts +7 more
TL;DR: The APOEε4 allele in this population may be associated with poor survival following ICH, and after adjusting for sex, age, hospital, and race, increased age and the presence of the APOE�4 allele significantly reduced in‐hospital survival.
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AMPA antagonist ZK200775 in patients with acute ischemic stroke - Possible glial cell toxicity detected by monitoring of S-100B serum levels
Jan-Willem Elting,Geert Sulter,Markku Kaste,Kennedy R. Lees,Hans C. Diener,Marc Hommel,Mark Versavel,A Teelken,Jacques De Keyser +8 more
TL;DR: The results suggest that in addition to neuronal dysfunction, glial cell toxicity may have occurred in patients with acute ischemic stroke, and it may be useful to introduce monitoring of serum markers of brain damage in phase 2 trials with glutamate receptor antagonists.
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Treating the acute stroke patient as an emergency: current practices and future opportunities.
TL;DR: Neuroprotective therapy could offer the prospect of a greater proportion of stroke patients receiving treatment, potentially before imaging and even in the ambulance setting, and could underlie the concept that ‘time is brain’ and that urgent intervention can limit cerebral damage.