Objective Quality of life (QOL) impairment of patients who visit an outpatient clinic for abdominal symptoms has not been clarified. We investigated symptom-related QOL impairment that led patients to seek medical care. Patients and Methods Abdominal symptom-related QOL was determined using the Izumo scale instrument in 172 patients who visited a clinic for their abdominal symptoms and in 961 healthy subjects who attended an annual health check. Results QOL was more strongly impaired in the patients with abdominal symptoms than in subjects who attended health checks. Patients with heartburn consulted physicians even when QOL impairment was minimal, while those with epigastric fullness tended to consult a physician only when QOL impairment was significant. Conclusion Abdominal symptom-related QOL impairment is considered to lead patients to seek medical care, though different symptoms have varying levels of influence.

Abdominal symptom-related QOL in individuals visiting an outpatient clinic and those attending an annual health check.

Effect of Changing the Method of Taking Dabigatran on Gastrointestinal Adverse Events

Abstract Background Practice has shown good efficacy in treating overlapping nonerosive reflux disease (NERD) and epigastric pain syndrome (EPS) symptoms through the use of methods for dispersing the liver and draining heat, harmonizing the stomach and lowering rebelliousness, however, there is a lack of high-level clinical evidence. We intend to evaluate the efficacy and safety of a representative formula of this approach, Tongjiang Granule (TJG), in patients with NERD and EPS symptoms overlapping with liver-stomach disharmony syndrome or liver-stomach depression-heat syndrome (NE-LSDS/LSDHS) in a multicenter clinical randomized controlled trial. Methods/design: This study is designed as a prospective, randomized, double-blind, placebo-controlled clinical trial in which 228 subjects with NE-LSDS/LSDHS will be recruited from 4 research centers. All subjects will be randomized into two groups after signing the informed consent form, the experimental group will be treated with TJG and the control group will be treated with the placebo to mimic TJG (l sachet/dose, 3 times/day, orally, 4 weeks). Visits is scheduled at 6 time points, 2 weeks before dosing and weeks 2, 4, 6, 8, and 10 after dosing. The primary outcome indicator will be the primary symptoms VAS score, the secondary outcome indicators will be the score of atypical and other symptoms, score of traditional Chinese medicine syndrome, visceral sensitivity index scale, patient-reported outcome scale, 36-item short-form scale, and hospital anxiety and depression scale. The safety indicators will include pre- and postdose blood, urine routine, stool routine with occult blood, liver and renal function, electrocardiogram, 24-hour esophageal pH impedance (1/3 of subjects), predose urine pregnancy test, and gastroscopy. Adverse events will also be promptly recorded. Discussion This study will evaluate the efficacy and safety of TJG for the treatment of patients with NE-LSDS/LSDHS, and the results will provide high-level clinical research-based evidence for the application of TJG NE-LSDS/LSDHS. Trial registration: ClinicalTrial.gov NCT05312463. Registered on 3 March 2022. All items from the World Health Organization Trial Registration Data Set can be found at https://classic.clinicaltrials.gov/ct2/show/NCT05312463. 

Assessment of the Effects of Tongjiang Granule in Treating Nonerosive Reflux Disease Overlapping Epigastric Pain Syndrome: Study protocol for a multicenter, double-blind, randomized controlled trial

The characteristics of symptoms reported by patients with various organic and functional upper gastroduodenal diseases have not been fully studied. We used a questionnaire-based survey to investigate abdominal symptoms of patients with reflux esophagitis, nonerosive reflux disease (NERD), peptic ulcers, and functional dyspepsia (FD). Seven hundred thirty-seven patients with those conditions responded to a questionnaire asking about the possible presence of nine kinds of upper abdominal symptoms. The mean number of symptoms reported was 3.2 ± 1.7, and patients with organic diseases tended to have a larger number. Approximately 60% of patients with NERD complained of heartburn and 30% of at least one dyspeptic symptom; more than 50% of patients with FD noted dyspeptic symptoms and 20% complained of reflux symptoms. We found a large overlap in the abdominal symptoms of NERD and FD patients, including the most troublesome symptoms. In summary, our questionnaire-based study showed that symptom-based classification of NERD and FD is not easy because of symptom overlap. Possible overlap of NERD and FD should always be considered.

Variety of symptoms reported by patients with upper gastrointestinal diseases

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Variety of symptoms reported by patients with upper gastrointestinal diseases