Kenji Hibi
Johns Hopkins University
12 Papers
518 Citations
Kenji Hibi is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 10, co-authored 12 publications. Previous affiliations of Kenji Hibi include Johns Hopkins University School of Medicine.
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Papers
Detecting Colorectal Cancer in Stool With the Use of Multiple Genetic Targets
Seung Myung Dong,Giovanni Traverso,Constance M. Johnson,Li Geng,Reyna Favis,Kevin A. Boynton,Kenji Hibi,Steven N. Goodman,Matthew D'Allessio,Philip B. Paty,Stanley R. Hamilton,David Sidransky,Francis Barany,Bernard Levin,Anthony P. Shuber,Kenneth W. Kinzler,Bert Vogelstein,Jin Jen,Jin Jen +18 more
TL;DR: Three genetic targets-TP53, BAT26, and K-RAS-were used to detect tumor-associated mutations in the stool prior to or without regard to the molecular analyses of the paired tumors, able to detect the majority of colorectal cancers by analyzing stool DNA for just three genetic markers.
383
•Journal Article
Molecular Detection of Genetic Alterations in the Serum of Colorectal Cancer Patients
Kenji Hibi,C. Rahj Robinson,Susan V. Booker,Li Wu,Stanley R. Hamilton,David Sidransky,Jin Jen +6 more
TL;DR: The frequent detection of p53 mutation in the serum of patients with early stage tumors suggests a possible use of this approach for clinical prognosis and cancer monitoring of colorectal cancer patients.
ΔNp63 induces β-catenin nuclear accumulation and signaling
Meera Patturajan,Shuji Nomoto,Matthias Sommer,Alexey Fomenkov,Kenji Hibi,Rachel Zangen,Nina Poliak,Joseph A. Califano,Barry Trink,Edward A. Ratovitski,David Sidransky +10 more
TL;DR: It is reported that ΔNp63 associates with the B56α regulatory subunit of protein phosphatase 2A (PP2A) and glycogen synthase kinase 3β (GSK3β) and leads to a dramatic inhibition of PP2A-mediated GSK3β reactivation, leading to a basis for their oncogenic properties.
196
•Journal Article
Serial Analysis of Gene Expression in Non-Small Cell Lung Cancer
Kenji Hibi,Qing Liu,Gary A. Beaudry,Stephen L. Madden,William H. Westra,Scott L. Wehage,Stephen C. Yang,Richard F. Heitmiller,Arthur H. Bertelsen,David Sidransky,Jin Jen +10 more
TL;DR: The results suggest that at least a portion of the transcripts identified by SAGE are frequently associated with lung cancer, and that their overexpression may contribute to lung tumorigenesis.
PGP9.5 As a candidate tumor marker for non-small-cell lung cancer
TL;DR: The results suggest that the increased expression of PGP9.5 is specifically associated with lung cancer development and may serve as a potential marker for the detection of lung cancer.