Kenichi Uto
Kobe University
21 Papers
53 Citations
Kenichi Uto is an academic researcher from Kobe University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 5, co-authored 14 publications.
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Papers
MicroRNA-124 inhibits the progression of adjuvant-induced arthritis in rats
TL;DR: It is found that miR-124 ameliorated AIA by suppressing critical prerequisites for arthritis development, such as RANKL and NFATc1, and is a candidate for therapeutic use for human rheumatoid arthritis.
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MicroRNA-124 inhibits TNF-α- and IL-6-induced osteoclastogenesis.
Kenichiro Ohnuma,Shimpei Kasagi,Kenichi Uto,Yoriko Noguchi,Yuji Nakamachi,Jun Saegusa,Seiji Kawano +6 more
TL;DR: The results indicate that miR-124 is important in inhibiting both RANKL-dependent and -independent osteoclast differentiation by suppressing NFATc1-mediated pathway.
Anticitrullinated Protein Antibody, But Not Its Titer, Is a Predictor of Radiographic Progression and Disease Activity in Rheumatoid Arthritis
Kazuko Shiozawa,Yoshiko Kawasaki,Takashi Yamane,R. Yoshihara,Yasushi Tanaka,Kenichi Uto,Shunichi Shiozawa +6 more
TL;DR: The results were demonstrable in cumulative SHS probability plots, and also repeatable in seronegative patients, which indicated that the titer of ACPA-2 is not a predictor of disease activity or radiographic progression in RA, and ACPA -2-negative patients, especially those with < 3 U/ml, showed minimal radiographic progress.
Exosomes derived from synovial fibroblasts from patients with rheumatoid arthritis promote macrophage migration that can be suppressed by miR-124-3p
Yuji Nakamachi,Kenichi Uto,Shinya Hayashi,Takaichi Okano,Akio Morinobu,Ryosuke Kuroda,Jun Saegusa +6 more
TL;DR: In this article , the role of exosomes in the pathology of Rheumatoid arthritis (RA) was investigated. But, the exosome is not a potent vehicle for intercellular communication.
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Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak
Zhenxiao Ren,Mitsuhiro Nishimura,Lidya Handayani Tjan,Koichi Furukawa,Yuki Kurahashi,Silvia Sutandhio,Kaito Aoki,Natsumi Hasegawa,Jun Arii,Kenichi Uto,Keiji Matsui,Itsuko Sato,Jun Saegusa,N. Godai,Kohei Takeshita,Masayuki Yamamoto,Tatsuya Nagashima,Yasuko Mori +17 more
TL;DR: It is revealed that effective immunity against the Delta variant was established in December 2021, however, prompt three-dose vaccination is needed to overcome Omicron’s outbreak.