Ken Ito
Osaka University
30 Papers
22 Citations
Ken Ito is an academic researcher from Osaka University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 22 publications.
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Papers
Overexpression of the Wilms' tumor gene WT1 in primary astrocytic tumors
Yusuke Oji,Tsuyoshi Suzuki,Yoko Nakano,Motohiko Maruno,Shin-ichi Nakatsuka,Tanyarat Jomgeow,Sakie Abeno,Naoya Tatsumi,Asumi Yokota,Sayaka Aoyagi,Tsutomu Nakazawa,Ken Ito,Keisuke Kanato,Toshiaki Shirakata,Sumiyuki Nishida,Naoki Hosen,Manabu Kawakami,Akihiro Tsuboi,Yoshihiro Oka,Katsuyuki Aozasa,Toshiki Yoshimine,Haruo Sugiyama +21 more
TL;DR: Treatment with WT1 antisense oligomers specifically inhibited growth of glioblastoma cell lines, U87‐MG, A172, and T‐98G, and may indicate that the WT1 gene plays an important role in tumorigenesis of primary astrocytic tumors.
141
Wilms’ tumor gene WT1 17AA(–)/KTS(–) isoform induces morphological changes and promotes cell migration and invasion in vitro
Tanyarat Jomgeow,Yusuke Oji,Naoko Tsuji,Yoko Ikeda,Ken Ito,Asako Tsuda,Tsutomu Nakazawa,Naoya Tatsumi,Nao Sakaguchi,Satoshi Takashima,Toshiaki Shirakata,Sumiyuki Nishida,Naoki Hosen,Manabu Kawakami,Akihiro Tsuboi,Yoshihiro Oka,Kazuyuki Itoh,Haruo Sugiyama +17 more
TL;DR: It is demonstrated that constitutive expression of the WT1 17AA(–)/KTS(–) isoform induces morphological changes characterized by a small‐sized cell shape in TYK‐nu cancer cells, which may provide a novel insight into the signaling pathway of theWT1 gene for its oncogenic functions.
83
Identification and characterization of a WT1 (Wilms Tumor Gene) protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes.
Fumihiro Fujiki,Yoshihiro Oka,Akihiro Tsuboi,Manabu Kawakami,Mai Kawakatsu,Hiroko Nakajima,Olga A. Elisseeva,Yukie Harada,Ken Ito,Zheyu Li,Naoya Tatsumi,Nao Sakaguchi,Tatsuya Fujioka,Tomoki Masuda,Masaki Yasukawa,Keiko Udaka,Ichiro Kawase,Yusuke Oji,Haruo Sugiyama +18 more
TL;DR: A WT1 protein-derived 16-mer peptide, WT1332, was identified as a helper epitope that could elicit WT1-specific CD4+ T-cell responses and should be useful for improvement of the efficacy of CTL epitope-based cancer vaccine targeting WT1 in the clinical setting.
63
•Journal Article
Overexpression of the Wilms' tumor gene WT1 in esophageal cancer.
Yusuke Oji,Masahiko Yano,Yoko Nakano,Sakie Abeno,Shin-ichi Nakatsuka,Ai Ikeba,Takushi Yasuda,Yoshiyuki Fujiwara,Shuji Takiguchi,Hirofumi Yamamoto,Seiichiro Fujita,Keisuke Kanato,Ken Ito,Tanyarat Jomgeow,Manabu Kawakami,Akihiro Tsuboi,Toshiaki Shirakata,Sumiyuki Nishida,Naoki Hosen,Yoshihiro Oka,Katsuyuki Aozasa,Morito Monden,Haruo Sugiyama +22 more
TL;DR: Results may indicate an important role of the WT1 gene in the tumorigenesis of ESCC, as expressed in esophageal squamous cell carcinoma.
48
•Journal Article
Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers.
Yusuke Oji,Shinichiro Miyoshi,Eigo Takahashi,Satoko Koga,Yoko Nakano,Yasushi Shintani,Hirohisa Hirabayashi,Akihide Matsumura,Keiji Iuchi,Ken Ito,Y Kishimoto,Akihiro Tsuboi,Kazuhiro Ikegame,Naoki Hosen,Yoshihiro Oka,Hiroyasu Ogawa,Hajime Maeda,S Hayashi,Ichiro Kawase,Haruo Sugiyama +19 more
TL;DR: Results indicated that the non-mutated, wild-type WT1 gene played an important role in de novo NSCLC.
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