Kelvin K. W. To
Li Ka Shing Faculty of Medicine, University of Hong Kong
374 Papers
1.2K Citations
Kelvin K. W. To is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 66, co-authored 293 publications. Previous affiliations of Kelvin K. W. To include Queen Mary University of London & Queen Mary Hospital.
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Papers
A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters.
Baozhong Zhang,Xiao-lei Wang,Shuofeng Yuan,Wen-Jun Li,Ying Dou,Vincent Kwok-Man Poon,Chris Chung-Sing Chan,Jian-Piao Cai,Kenn Ka-Heng Chik,Kaiming Tang,Chris Chun-Yiu Chan,Y.F. Hu,Jingchu Hu,Smaranda Ruxandra Badea,Hua-Rui Gong,Xuansheng Lin,Hin Chu,Xuechen Li,Kelvin K. W. To,Li Liu,Zhiwei Chen,Ivan Hung,Kwok-Yung Yuen,Jasper Fuk-Woo Chan,Jian-Dong Huang,Jian-Dong Huang +25 more
TL;DR: In this article, linkerimmunodominant site (LIS) vaccine candidates were proposed for the Coronavirus Disease 2019 (COVID-19) pandemic.
High prevalence of four novel astrovirus genotype species identified from rodents in China.
Kelvin K. W. To,Wan-Mui Chan,Kenneth S.M. Li,Carol S. F. Lam,Zhiwei Chen,Herman Tse,Susanna K. P. Lau,Patrick C. Y. Woo,Kwok-Yung Yuen +8 more
TL;DR: Phylogenetic analysis of the ORF1b region, which encodes the RdRp, showed that there were four distinct clusters (clusters A, B, C and D), and cluster D was most closely related to the rodent astrovirus previously identified in Hong Kong.
Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses
Runhong Zhou,Kelvin K. W. To,Yik Chun Wong,Li Liu,Biao Zhou,Xin Li,Haode Huang,Yufei Mo,Tsz Yat Luk,Thomas Tsz Kan Lau,Pauline Yeung,Wai-Ming Chan,Alan Ka Lun Wu,Alan Ka Lun Wu,Kwok Cheung Lung,Owen Tak-Yin Tsang,Wai Shing Leung,Ivan Hung,Kwok-Yung Yuen,Zhiwei Chen +19 more
TL;DR: Investigating acute SARS-CoV-2 infection resulted in broad immune cell reduction including T cells, NK cell, monocytes and dendritic cells (DCs), providing evidence that impaired DCs, together with timely inverted strong antibody but weak CD8 T cell responses might contribute to acute COVID-19 pathogenesis and have implications to vaccine development.
A prospective follow-up on thyroid function, thyroid autoimmunity and long COVID among 250 COVID-19 survivors
David T W Lui,Kimberly Hang Tsoi,Chi-Ho Lee,Chloe Y Y Cheung,Carol H.Y. Fong,Alan Chun Hong Lee,Anthony Raymond Tam,P.K.P. Pang,Tip Yin Ho,Chun-Yiu Law,Ching-Wan Lam,Kelvin K. W. To,Wing Sun Chow,Yu Cho Woo,Ivan Hung,Kathryn C.B. Tan,Karen S.L. Lam +16 more
TL;DR: In this paper , the authors evaluated the evolution of thyroid function and autoimmunity among COVID-19 survivors over 6 months in relation to interferon beta-1b treatment and long COVID.