Kelly Townsend
University of Birmingham
8 Papers
37 Citations
Kelly Townsend is an academic researcher from University of Birmingham. The author has contributed to research in topics: Ubiquitin ligase & Vitamin D and neurology. The author has an hindex of 8, co-authored 8 publications.
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Papers
The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage
Grant S. Stewart,Stephanie Panier,Stephanie Panier,Kelly Townsend,Abdallah Al-Hakim,Nadine K. Kolas,Edward S. Miller,Shinichiro Nakada,Jarkko Ylanko,Jarkko Ylanko,Signe Olivarius,Megan Mendez,Ceri E. Oldreive,Jan Wildenhain,Andrea Tagliaferro,Laurence Pelletier,Laurence Pelletier,Nadine Taubenheim,Anne Durandy,Philip J. Byrd,Tatjana Stankovic,A. Malcolm R. Taylor,Daniel Durocher,Daniel Durocher +23 more
TL;DR: It is reported that the ubiquitin ligase RNF168 is mutated in the RIDDLE syndrome, a recently discovered immunodeficiency and radiosensitivity disorder and their loss is the likely cause of the cellular and developmental phenotypes associated with RIDdLE syndrome.
802
Biological actions of extra-renal 25-hydroxyvitamin D-1α-hydroxylase and implications for chemoprevention and treatment
TL;DR: The demonstration of 1alpha-hydroxylase activity in tumors and their equivalent normal tissues has implications for both the treatment and prevention of cancers.
159
Kaposi's Sarcoma-Associated Herpesvirus Infection of Endothelial Cells Inhibits Neutrophil Recruitment through an Interleukin-6-Dependent Mechanism: a New Paradigm for Viral Immune Evasion
Lynn M. Butler,Hannah C. Jeffery,Rachel Wheat,Peter C Rae,Kelly Townsend,Khaled R. Alkharsah,Thomas F. Schulz,Gerard B. Nash,David J. Blackbourn +8 more
TL;DR: A novel paracrine mode of KSHV immune evasion is revealed, resulting in reduced recruitment of neutrophils, a cell type whose antiviral and antitumor roles are becoming increasingly appreciated, and have implications for the understanding of the contribution of hIL-6 to the pathogenesis of other inflammatory disorders and tumors in which this cytokine is abundant.
38
Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis
Garry G. Sedgwick,Kelly Townsend,Ashley Martin,Neil J. Shimwell,Roger J.A. Grand,Grant S. Stewart,Jakob Nilsson,Andrew S. Turnell +7 more
TL;DR: Novel functions for TIF1γ during mitosis are defined and it is suggested that a reduction in APC/C ubiquitin ligase activity promotes SAC activation.
32
Autocrine metabolism of vitamin D in normal and malignant breast tissue.
Kelly Townsend,Claire M. Banwell,Michelle Guy,Kay W. Colston,Janine Mansi,Paul M. Stewart,Moray J. Campbell,Martin Hewison +7 more
TL;DR: The data indicate that the vitamin D–activating enzyme 1α-hydroxylase is up-regulated in breast tumors, and the enzymes involved in autocrine metabolism of vitamin D in breast tissue may provide important targets for both the prevention and treatment of breast cancer.