Kelly S. Doran
University of Colorado Denver
134 Papers
214 Citations
Kelly S. Doran is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Streptococcus agalactiae & Biology. The author has an hindex of 40, co-authored 103 publications. Previous affiliations of Kelly S. Doran include University of California, San Diego & San Diego State University.
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Papers
Contribution of Lethal Toxin and Edema Toxin to the Pathogenesis of Anthrax Meningitis
TL;DR: This work investigates the contribution of the individual toxins to BBB disruption using isogenic toxin mutants deficient in lethal factor, ΔLF, and edema factor, and observed that toxin expression reduced bacterial intracellular survival by inducing the bulk degradative autophagy pathway in host cells.
Complete m6A and m4C methylomes for group B streptococcal clinical isolates CJB111, A909, COH1, and NEM316
Haider S. Manzer,Kelly S. Doran +1 more
TL;DR: DNA methylation is a common mechanism for both phage defense and transcriptional regulation in Group B Streptococcus isolates and the m6A and m4C methylomes of four clinical GBS isolates are reported.
Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors.
Nina M. van Sorge,Daniel A. Bonsor,Liwen Deng,Erik Lindahl,Verena Schmitt,Mykola Serhiiovych Lyndin,Mykola Serhiiovych Lyndin,Alexej Schmidt,Olof Nilsson,Jaime Brizuela,Elena Boero,Eric J. Sundberg,Eric J. Sundberg,Jos A. G. van Strijp,Kelly S. Doran,Bernhard B. Singer,Gunnar Lindahl,Alex J. McCarthy,Alex J. McCarthy +18 more
TL;DR: In this paper, surface-expressed β protein of group B Streptococcus (GBS) was found to bind to human CEACAM1 and CEACACAM5 receptors and a crystal structure of the complex showed that an IgSF domain in β represents a novel Ig-fold subtype called IgI3, in which unique features allow binding to CEACam1.
Global genome analysis identifies glycolipids and lipoteichoic acid alanylation as contributors to Group B streptococcal diabetic wound infection
Luke R. Joyce,Madeline S Akbari,Dustin T. Nguyen,Brady L. Spencer,Kevin S. McIver,Alexander R. Horswill,Kelly S. Doran,Rebecca A. Keogh +7 more
Genomic Analyses Identify Manganese Homeostasis as a Driver of Group B Streptococcal Vaginal Colonization
Lindsey R. Burcham,Madeline S Akbari,Norhan Alhajjar,Rebecca A. Keogh,Jana N. Radin,Thomas E. Kehl-Fie,Ashton T. Belew,Najib M. El-Sayed,Kevin S. McIver,Kelly S. Doran +9 more
TL;DR: It is suggested that Mn2+ homeostasis is an important process contributing to GBS survival in the FRT, and a mutant lacking mtsA is hypersusceptible to oxidative stress induced by both H2O2 and paraquat and has a severe fitness defect compared to WT GBS in the murine vaginal tract.