Kelly De Sousa
University of Paris
7 Papers
Kelly De Sousa is an academic researcher from University of Paris. The author has contributed to research in topics: Internal medicine & Aldosterone. The author has an hindex of 2, co-authored 4 publications.
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Papers
Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma
Kelly De Sousa,Sheerazed Boulkroun,Stéphanie Baron,Kazutaka Nanba,Maxime Wack,William E. Rainey,Angélique Rocha,Isabelle Giscos-Douriez,Tchao Meatchi,Laurence Amar,Simon Travers,Fabio L. Fernandes-Rosa,Maria-Christina Zennaro +12 more
TL;DR: Investigation of genetic, cellular, and molecular heterogeneity of different aldosterone-producing structures in adrenals with APA suggests complex mechanisms underlying APA development.
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Identification of risk loci for primary aldosteronism in genome-wide association studies
Edith Le Floch,Teresa Cosentino,Casper Larsen,Felix Beuschlein,Martin Reincke,Laurence Amar,Gian Paolo Rossi,Kelly De Sousa,Stéphanie Baron,Sophie Chantalat,Benjamin Saintpierre,Livia Lenzini,Arthur Frouin,I. Giscos-Douriez,Matthis Ferey,Alaa B Abdellatif,Tchao Meatchi,Jean-Philippe Empana,Xavier Jouven,Christian Gieger,Melanie Waldenberger,Annette Peters,Daniele Cusi,Erika Salvi,Pierre Meneton,Mathilde Touvier,Mélanie Deschasaux,Nathalie Druesne-Pecollo,Sheerazed Boulkroun,Fabio L. Fernandes-Rosa,Jean-François Deleuze,Xavier Jeunemaitre,Maria-Christina Zennaro +32 more
TL;DR: In this article , the authors performed a genome-wide association study in a discovery cohort of 562 cases and 950 controls and identified three main loci on chromosomes 1, 13 and X.
Somatic mutations in adrenals from patients with primary aldosteronism not cured after adrenalectomy suggest common pathogenic mechanisms between unilateral and bilateral disease
Inès Hacini,Kelly De Sousa,Sheerazed Boulkroun,Tchao Meatchi,Laurence Amar,Maria-Christina Zennaro,Fábio L. Fernandes-Rosa +6 more
TL;DR: In this article, the authors analyzed clinical data of patients with primary aldosteronism without biochemical success after adrenalectomy as well as the histological and genetic characteristics of their adrenal glands.
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Regulation of Aldosterone Secretion by Substance P and the Neurokinin Type 1 Receptor in Aldosterone-Producing Adenomas.
Céline Duparc,Sylvie Renouf,Margot D'agostino,Kelly De Sousa,Laurence Amar,Guillaume Defortescu,Gilles Manceau,Jean-Christophe Sabourin,Fabio L. Fernandes-Rosa,Maria-Christina Zennaro,Tchao Meatchi,Gaël Nicolas,Estelle Louiset,H. Lefebvre +13 more
TL;DR: This study investigates the role of Substance P and the Neurokinin Type 1 Receptor in regulating aldosterone secretion in Aldosterone-Producing Adenomas, a common cause of primary aldosteronism, and finds evidence of their involvement in adenoma pathophysiology.
Regulation of Aldosterone Secretion by Substance P and the NK1 Receptor in Aldosterone-Producing Adenomas
Antoine-Guy Lopez,Céline Duparc,Sylvie Renouf,Margot D'agostino,Kelly De Sousa,Laurence Amar,G. Defortescu,Gilles Manceau,Jean-Christophe Sabourin,Fabio L. Fernandes-Rosa,Maria-Christina Zennaro,Tchao Meatchi,Gaël Nicolas,Estelle Louiset,Hervé Lefebvre +14 more
TL;DR: This study investigates the role of substance P and the NK1 receptor in aldosterone-producing adenomas, a common cause of primary aldosteronism, and finds that substance P stimulates aldosterone secretion in a subset of adenomas through the NK1 receptor.