Keith Westerman
6 Papers
29 Citations
Keith Westerman is an academic researcher. The author has contributed to research in topics: Hepcidin & Iron deficiency. The author has an hindex of 3, co-authored 6 publications.
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Papers
Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency.
Matthew M. Heeney,Matthew M. Heeney,Dongjing Guo,Luigia De Falco,Dean R. Campagna,Gordana Olbina,Paige P.-C. Kao,Klaus Schmitz-Abe,Fedik Rahimov,Patrick Gutschow,Keith Westerman,Vaughn Ostland,Tracy Jackson,Robert J. Klaassen,Kyriacos Markianos,Karin E. Finberg,Achille Iolascon,Mark Westerman,Wendy B. London,Wendy B. London,Mark D. Fleming +20 more
TL;DR: Iron-refractory iron deficiency anemia (IRIDA) is characterized by congenital iron deficiency that is poorly responsive to oral iron treatment and biallelic mutations in TMPRSS6 are found in most patients.
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Patent
Anti-hepcidin antibodies and uses thereof
Mark Westerman,Vaughn Ostland,Huiling Han,Patrick Gutschow,Keith Westerman,Gordana Olbina +5 more
- 13 Mar 2014
TL;DR: In this paper, the use of humanized antibodies which specifically bind to hepcidin and regulate iron homeostasis for the treatment of a disease or condition associated with HE is discussed.
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A Novel Dual Monoclonal Sandwich ELISA for Human Erythroferrone
Huiling Han,Keith Westerman,Vaughn Ostland,Patrick Gutschow,Gordana Olbina,Jacqueline da Silva Guimarães,Juçara Gastaldi Cominal,Ana Maria de Souza,Ana Cristina Silva Pinto,Stefano Rivella,Yelena Ginzburg,Mark D. Fleming,Mark Westerman +12 more
TL;DR: The first dual monoclonal sandwich ELISA for serum measurement was developed to study the biological function and potential clinical applications of ERFE in humans and to test the concept that serum ERFE concentrations would be elevated in blood disorders associated with ineffective erythropoiesis.
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Validation of the Intrinsic Hepcidin IDxTM Test, an LDT for Clinical Hepcidin Assessment
Patrick Gutschow,Keith Westerman,Huiling Han,Vaughn Ostland,Gordana Olbina,William A. Paxton,Mark Westerman +6 more
TL;DR: A high-affinity monoclonal antibody to hepcidin was developed and used to produce a competitive ELISA (C-ELISA) similar to the authors' first RUO test, which was validated using CLIA analytical method validation guidelines.
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A Novel Sandwich ELISA to Quantify Erythroferrone in Mouse Serum
Patrick Gutschow,Huiling Han,Gordana Olbina,Keith Westerman,Eileen Westerman,Marc Ruiz Martinez,Yelena Ginzburg,Elizabeta Nemeth,Tomas Ganz,Vaughn Ostland +9 more
TL;DR: This validated ELISA can quantify mouse serum ERFE in both healthy and diseased mouse models and can be used to study the pathobiology of this erythroid regulator in diseases associated with ineffective erythropoiesis.
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