Keith S. Wong
University of Toronto
19 Papers
18 Citations
Keith S. Wong is an academic researcher from University of Toronto. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 10, co-authored 15 publications. Previous affiliations of Keith S. Wong include Princess Margaret Cancer Centre.
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Papers
Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality
Jo Ishizawa,Sarah F. Zarabi,Sarah F. Zarabi,R. Eric Davis,Ondrej Halgas,Ondrej Halgas,Takenobu Nii,Yulia Jitkova,Ran Zhao,Jonathan St-Germain,Lauren Heese,Grace Egan,Vivian Ruvolo,Samir H. Barghout,Samir H. Barghout,Yuki Nishida,Rose Hurren,Wencai Ma,Marcela Gronda,Todd M. Link,Keith S. Wong,Keith S. Wong,Mark F. Mabanglo,Kensuke Kojima,Kensuke Kojima,Gautam Borthakur,Neil MacLean,Man Chun John Ma,Andrew B. Leber,Mark D. Minden,Mark D. Minden,Walid A. Houry,Hagop M. Kantarjian,Martin Stogniew,Brian Raught,Brian Raught,Emil F. Pai,Aaron D. Schimmer,Aaron D. Schimmer,Michael Andreeff +39 more
TL;DR: It is shown that imipridones bind ClpP non-covalently and induce proteolysis by diverse structural changes, suggesting a general concept of inducing cancer cell lethality through activation of mitochondrial proteolytic activity.
263
The Role of ClpP Protease in Bacterial Pathogenesis and Human Diseases.
TL;DR: The biochemical and cellular activities of ClpP are discussed along with the mechanisms by whichClpP affects bacterial pathogenesis and various human diseases.
130
Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death.
Keith S. Wong,Mark F. Mabanglo,Thiago V. Seraphim,Thiago V. Seraphim,Antonio Mollica,Yu Qian Mao,Kamran Rizzolo,Elisa Leung,Mohamed Taha Moutaoufik,Larissa Hoell,Sadhna Phanse,Jordan D. Goodreid,Leandro R.S. Barbosa,Carlos H.I. Ramos,Mohan Babu,Vito Mennella,Robert A. Batey,Aaron D. Schimmer,Walid A. Houry +18 more
TL;DR: These ADEP analogs that are potent dysregulators of the human mitochondrial ClpP interact tightly with HsClpP, causing the protease to non-specifically degrade model substrates, suggesting a therapeutic potential for ADEPs in cancer treatment.
91
Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.
Jordan D. Goodreid,John Janetzko,John P. Santa Maria,Keith S. Wong,Elisa Leung,Bryan T. Eger,Steve Bryson,Steve Bryson,Emil F. Pai,Scott D. Gray-Owen,Suzanne Walker,Walid A. Houry,Robert A. Batey +12 more
TL;DR: The synthesis and biological evaluation of 14 novel ADEPs against a variety of pathogenic Gram-negative and Gram-positive organisms is outlined and the co-crystal structure of an ADEP-ClpP complex derived from N. meningitidis was solved.
48
The MoxR ATPase RavA and Its Cofactor ViaA Interact with the NADH:Ubiquinone Oxidoreductase I in Escherichia coli
Keith S. Wong,Jamie Snider,Chris Graham,Jack Greenblatt,Andrew Emili,Mohan Babu,Walid A. Houry +6 more
TL;DR: Systematic analysis of mutant strains of ravA and viaA indicated that RavA-ViaA sensitizes cells to sublethal concentrations of aminoglycosides, and this effect was dependent on RavA's ATPase activity, and on the presence of specific subunits of NADH:ubiquinone oxidoreductase I (Nuo Complex, or Complex I).