Keith S. Robinson
Imperial College London
8 Papers
Keith S. Robinson is an academic researcher from Imperial College London. The author has contributed to research in topics: Effector & Biology. The author has an hindex of 8, co-authored 8 publications.
Chat about Author
Papers
Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements.
Alexander Wong,Jaclyn S. Pearson,Michael D. Bright,Diana Munera,Keith S. Robinson,Sau Fung Lee,Gad Frankel,Elizabeth L. Hartland +7 more
TL;DR: The findings have highlighted the multifunctional nature of the effectors and their ability to participate in redundant, synergistic or antagonistic relationships, acting in a co‐ordinated spatial and temporal manner on different host organelles and cellular pathways during infection.
393
A type III effector antagonizes death receptor signalling during bacterial gut infection
Jaclyn S. Pearson,Cristina Giogha,Sze Ying Ong,Catherine Kennedy,Michelle Kelly,Keith S. Robinson,Tania Wong Fok Lung,Ashley Mansell,Patrice Riedmaier,Claire Vl Oates,Ali Zaid,Sabrina Mühlen,Valerie F. Crepin,Oliver Marchès,Ching-Seng Ang,Nicholas A. Williamson,Lorraine A. O'Reilly,Lorraine A. O'Reilly,Aleksandra Bankovacki,Ueli Nachbur,Giuseppe Infusini,Andrew I. Webb,Andrew I. Webb,John Silke,John Silke,Andreas Strasser,Andreas Strasser,Gad Frankel,Elizabeth L. Hartland,Elizabeth L. Hartland +29 more
TL;DR: The activity of NleB suggests that EPEC and other attaching and effacing pathogens antagonize death-receptor-induced apoptosis of infected cells, thereby blocking a major antimicrobial host response.
Salmonella bongori provides insights into the evolution of the salmonellae
Maria Fookes,Gunnar N. Schroeder,Gemma C. Langridge,Carlos J. Blondel,Caterina Mammina,Thomas R. Connor,Helena M. B. Seth-Smith,Georgios S. Vernikos,Keith S. Robinson,Mandy Sanders,Nicola K. Petty,Robert A. Kingsley,Andreas J. Bäumler,Sean Paul Nuccio,Inés Contreras,Carlos A. Santiviago,Duncan J. Maskell,Paul A. Barrow,Tom J. Humphrey,Antonino Nastasi,Mark Roberts,Gad Frankel,Julian Parkhill,Gordon Dougan,Nicholas R. Thomson +24 more
TL;DR: This work suggests that S. bongori has inherited the ancestral Salmonella virulence gene set, but has adapted by incorporating virulence determinants that resemble those employed by EPEC.
NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection
Cordula Hemrajani,Cedric N. Berger,Keith S. Robinson,Olivier Marchès,Aurelie Mousnier,Gad Frankel +5 more
TL;DR: It is demonstrated that the NleH family effectors, homologs of the Shigella effector kinase OspG, blocks apoptosis and are inhibitors of apoptosis that may act through BI-1 to carry out their cytoprotective function.
162
Bax Inhibitor 1 in apoptosis and disease
TL;DR: Manipulation of BI-1 has the potential for significant therapeutic benefit in a wide range of human diseases, including in tissue homeostasis and as a regulator of cellular stress.
86