Keith A. Stubbs
University of Western Australia
150 Papers
794 Citations
Keith A. Stubbs is an academic researcher from University of Western Australia. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 33, co-authored 138 publications. Previous affiliations of Keith A. Stubbs include Flinders University & Simon Fraser University.
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Papers
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.
Scott A. Yuzwa,Matthew S. Macauley,J.E. Heinonen,Xiaoyang Shan,Rebecca J. Dennis,Yuan He,Garrett E. Whitworth,Keith A. Stubbs,Ernest J. McEachern,Gideon J. Davies,David J. Vocadlo +10 more
TL;DR: Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in AD.
685
Perturbation of Indole-3-Butyric Acid Homeostasis by the UDP-Glucosyltransferase UGT74E2 Modulates Arabidopsis Architecture and Water Stress Tolerance
Vanesa B. Tognetti,Olivier Van Aken,Olivier Van Aken,Kris Morreel,Korneel Vandenbroucke,Brigitte van de Cotte,Inge De Clercq,Sheila D.S. Chiwocha,Ricarda Fenske,Els Prinsen,Wout Boerjan,Bernard Genty,Keith A. Stubbs,Dirk Inzé,Frank Van Breusegem +14 more
TL;DR: The results reveal that IBA and IBA-Glc are important regulators of morphological and physiological stress adaptation mechanisms and provide molecular evidence for the interplay between hydrogen peroxide and auxin homeostasis through the action of an IBA UGT.
464
Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity
Rebecca J. Dennis,Edward J. Taylor,Matthew S. Macauley,Keith A. Stubbs,Johan P. Turkenburg,Sam Hart,Gary N Black,David J. Vocadlo,Gideon J. Davies +8 more
TL;DR: Mutagenesis and kinetics studies show that the bacterial enzyme, very similarly to its human counterpart, operates via an unusual 'substrate-assisted' catalytic mechanism, which will inform the rational design of enzyme inhibitors.
205
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise
Garrett E. Whitworth,Matthew S. Macauley,Keith A. Stubbs,Rebecca J. Dennis,Edward J. Taylor,Gideon J. Davies,Ian R. Greig,David J. Vocadlo +7 more
TL;DR: The potency of NAG-thiazoline, its transition state mimicry, and its lack of traditional transition state-like design features suggest that potent rationally designed glycosidase inhibitors can be developed that exploit variation in transition state poise.
Carrageenan catabolism is encoded by a complex regulon in marine heterotrophic bacteria
Elizabeth Ficko-Blean,Aurélie Préchoux,François Thomas,Tatiana Rochat,Robert Larocque,Yongtao Zhu,Mark Stam,Sabine Genicot,Murielle Jam,Alexandra Calteau,Benjamin Thomas Viart,David Ropartz,David Pérez-Pascual,Gaëlle Correc,Maria Matard-Mann,Keith A. Stubbs,Hélène Rogniaux,Alexandra Jeudy,Tristan Barbeyron,Claudine Médigue,Mirjam Czjzek,David Vallenet,Mark J. McBride,Eric Duchaud,Gurvan Michel +24 more
TL;DR: The complete catabolic pathway for carrageenans, major cell wall polysaccharides of red macroalgae, in the marine heterotrophic bacterium Zobellia galactanivorans is described and an extension on the definition of bacterial PUL-mediated poly Saccharide digestion is extended.