Keisuke Okabe
University of Toyama
16 Papers
4 Citations
Keisuke Okabe is an academic researcher from University of Toyama. The author has contributed to research in topics: NAD+ kinase & Nicotinamide adenine dinucleotide. The author has an hindex of 9, co-authored 16 publications.
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Papers
NAD metabolism: Implications in aging and longevity.
TL;DR: The basic functions of the enzymes involved in NAD synthesis and degradation, as well as the outcomes of their dysregulation in various aging processes are summarized and a particular focus is given on the role of NAD metabolism in the longevity of various organisms.
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NAD Metabolism in Cancer Therapeutics.
TL;DR: NAD metabolism is implicated in cancer pathogenesis beyond energy metabolism and considered a promising therapeutic target for cancer treatment, and recent findings with respect to NAD metabolism are presented.
Implications of altered NAD metabolism in metabolic disorders
TL;DR: Current knowledge on the implications of NAD metabolism in metabolic diseases is summarized and the outcomes of recent human clinical trials are discussed to investigate the safety, pharmacokinetics, and efficacy against metabolic disorders such as glucose intolerance.
HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance
Akiko Takikawa,Arshad Mahmood,Allah Nawaz,Tomonobu Kado,Keisuke Okabe,Seiji Yamamoto,Aminuddin Aminuddin,Satoko Senda,Koichi Tsuneyama,Koichi Tsuneyama,Masashi Ikutani,Yasuharu Watanabe,Yoshiko Igarashi,Yoshinori Nagai,Yoshinori Nagai,Kiyoshi Takatsu,Koizumi Keiichi,Johji Imura,Nobuhito Goda,Masakiyo Sasahara,Michihiro Matsumoto,Kumiko Saeki,Takashi Nakagawa,Shiho Fujisaka,Isao Usui,Kazuyuki Tobe +25 more
TL;DR: The in vitro study revealed that lipopolysaccharide-treated bone marrow–derived macrophages directly inhibited the expression of angiogenic factors in 3T3-L1 preadipocytes, indicating that macrophage HIF-1α is involved not only in the formation of CLSs, further enhancing the inflammatory responses, but also in the inhibition of neoangiogenesis in preadIPocytes.
Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity.
Shiho Fujisaka,Isao Usui,Isao Usui,Allah Nawaz,Yoshiko Igarashi,Keisuke Okabe,Yukihiro Furusawa,Shiro Watanabe,Seiji Yamamoto,Masakiyo Sasahara,Yoshiyuki Watanabe,Yoshinori Nagai,Kunimasa Yagi,Takashi Nakagawa,Kazuyuki Tobe +14 more
TL;DR: It is demonstrated that BFT modifies the gut microbiota with an increase in AKK, which may contribute to improving gut barrier function and preventing metabolic endotoxemia, leading to attenuation of diet-induced inflammation and glucose intolerance.