Keisuke Handa
Kanagawa Dental College
28 Papers
51 Citations
Keisuke Handa is an academic researcher from Kanagawa Dental College. The author has contributed to research in topics: Dental follicle & Cementum. The author has an hindex of 10, co-authored 26 publications. Previous affiliations of Keisuke Handa include Tohoku University & Health Sciences University of Hokkaido.
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Papers
Regulation of Notch1 gene expression by p53 in epithelial cells.
Takashi Yugawa,Keisuke Handa,Mako Narisawa-Saito,Shin Ichi Ohno,Masatoshi Fujita,Tohru Kiyono +5 more
TL;DR: A novel link between p53 and Notch1 in keratinocyte differentiation upon genotoxic stress is demonstrated and a novel tumor suppressor mechanism of p53 in the development of squamous cell carcinomas, including HPV-induced tumors is suggested.
205
Progenitor cells from dental follicle are able to form cementum matrix in vivo.
Keisuke Handa,Masahiro Saito,Akira Tsunoda,M. Yamauchi,Shintaro Hattori,S. Sato,Minoru Toyoda,Toshio Teranaka,A. Sampath Narayanan +8 more
TL;DR: Results indicated that the bovine dental follicle cells (BDFC) contained cementoblast progenitors that were able to differentiate to cementoblasts in vivo, and indicated that they are phenotypically distinct from BAOB and BPDL.
154
Characterization of Dental Epithelial Progenitor Cells Derived from Cervical-loop Epithelium in a Rat Lower Incisor
Shintarou Kawano,Masahiro Saito,Keisuke Handa,Takahiko Morotomi,Takashi Toyono,Yuji Seta,Norifumi Nakamura,Takashi Uchida,Kuniaki Toyoshima,Masamichi Ohishi,Hidemitsu Harada,Hidemitsu Harada +11 more
TL;DR: It is suggested that fibroblast growth factor 10 plays a role in coupling mitogenesis of the cervical-loop cells and the production of stratum intermedium cells in rat incisors and stimulated proliferation of dental progenitor cells and subsequently increased the number of cells expressing alkaline phosphatase.
80
E6AP-Dependent Degradation of DLG4/PSD95 by High-Risk Human Papillomavirus Type 18 E6 Protein
Keisuke Handa,Takashi Yugawa,Mako Narisawa-Saito,Shin Ichi Ohno,Masatoshi Fujita,Tohru Kiyono +5 more
TL;DR: DLG4/PSD95, another human homologue of the Drosophila discs large tumor suppressor, is described as a novel E6 target and results suggest that DLG4 may function as a tumor suppressionor in the development of HPV-associated cancers.
80
Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation
Tatsuya Hasegawa,V. Venkata Suresh,Yoshio Yahata,Masato Nakano,Shigeto Suzuki,Shigeki Suzuki,Satoru Yamada,Hideki Kitaura,Itaru Mizoguchi,Yuichiro Noiri,Keisuke Handa,Keisuke Handa,Masahiro Saito +12 more
TL;DR: In this article, the authors investigated inflammatory-related genes that regulate AP development and found that macrophage-derived CXCL9, which acts through CXCR3, is recruited by progressed AP.