Objective: To discuss and analyze the difference in thyroid hormone reference ranges between normal pregnant women and normal adults, and study the thyroid dysfunction in pregnant women during pregnancy.
Methods: Blood samples of 166 pregnant women and 50 non-pregnant women were randomly collected, to detect Thyroid Stimulating Hormone (TSH), Free Triiodothyronine (FT3), Free Thyroxine (FT4), Total Triiodothyronine (TT3) and Total Thyroxine (TT4).
Results: The ratio of thyroid dysfunction was 9.64% (16/166) by using normal thyroid hormone reference ranges of pregnant women as an index, while the ratio of thyroid dysfunction was 1.20% (2/166) by using the normal thyroid hormone reference ranges of non-pregnant women as an index. The difference in thyroid hormone reference ranges between the two methods was statistically significant (P<0.05).
Conclusions: There were significant differences in thyroid hormone levels between pregnant women and non-pregnant women, and between women during different stages of pregnancy, and the ratio of thyroid dysfunction during pregnancy was 9.64%; therefore, thyroid function screening is necessary in all pregnant women.

/pdf/difference-of-thyroid-hormone-reference-ranges-in-diagnosis-4nswuc2vis.pdf

Difference of thyroid hormone reference ranges in diagnosis of thyroid functions between normal pregnant women in the early, middle and late pregnancy and normal adults

Objective To investigate the thyroid related hormones of differenct pregnant trimesters and put forward suggestions about related routine tests.Methods 1 500 cases of pregnant women at different trimesters were retrospectively analyzed,including 500 cases in first trimester( 12 weeks),500 cases in second trimester(13-27 weeks) and 500 cases in third trimester(28 weeks to delivery).200 healthy non-pregnant women were selected as control group.The serum thyroid hormone levels were tested,such as free 3,5,3'-triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH),thyroglobulin antibody(A-TG) and anti-thyroid peroxidase antibody(TPOAb).Statistical analysis were performed.Results There was statistical significance between the pregnant group and control group in terms of serum thyroid hormones levels(P 0.05).The morbidity rate of pregnant group was higher(8.53%) than that of control group.The difference among the different trimesters showed statistical significance(P 0.05).From first to third trimesters,TSH levels increased gradually while FT3,FT4 decreased gradually.The positive rates of ATG and TPOAb were 4.6% and3.6%,respectively for the third trimester,which were lower than first(12.4%,11.4%) and second trimester groups(9.0%,8.2%).Conclusions There is close relationship between serum thyroid hormones level and trimesters.The pregnant women should be screened for serum thyroid hormones levels and intervened if necessary,in order to achieve better delivery.

The analysis of thyroid hormone levels of different pregnant trimesters

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The analysis of thyroid hormone levels of different pregnant trimesters