Ke Li
Hunan University
7 Papers
25 Citations
Ke Li is an academic researcher from Hunan University. The author has contributed to research in topics: Chemistry & Furin. The author has an hindex of 5, co-authored 7 publications.
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Papers
In Situ Localization of Enzyme Activity in Live Cells by a Molecular Probe Releasing a Precipitating Fluorochrome
Hong-Wen Liu,Ke Li,Xiaoxiao Hu,Longmin Zhu,Qiming Rong,Yongchao Liu,Xiao-Bing Zhang,Jens Hasserodt,Fengli Qu,Weihong Tan +9 more
TL;DR: An excited-state intramolecular proton transfer-based solid-state fluorophore HTPQ was developed that is strictly insoluble in water and emits intense fluorescence in the solid state, with λex/em =410/550 nm, thus making it far better suited to use with a commercial confocal microscope.
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A mitochondrial-targeted prodrug for NIR imaging guided and synergetic NIR photodynamic-chemo cancer therapy.
Hong-Wen Liu,Hong-Wen Liu,Xiaoxiao Hu,Ke Li,Yongchao Liu,Qiming Rong,Longmin Zhu,Lin Yuan,Fengli Qu,Xiao-Bing Zhang,Weihong Tan +10 more
TL;DR: Nontoxic prodrugs, especially activated by tumor microenvironment, are urgently required for reducing the side effects of cancer therapy.
Molecular engineering of organic-based agents for in situ bioimaging and phototherapeutics
TL;DR: In this article, the authors summarize the in situ molecular immobilization strategies to retain small-molecule agents inside cells/lesions to prevent their diffusion in living organisms and introduce the application of these strategies for in situ imaging of biomolecules and precision treatment.
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A de novo strategy to develop NIR precipitating fluorochrome for long-term in situ cell membrane bioimaging
Ke Li,Yifan Lyu,Yan Huang,Shuai Xu,Hong-Wen Liu,Lanlan Chen,Tian-Bing Ren,Mengyi Xiong,Shuangyan Huan,Lin Yuan,Xiao-Bing Zhang,Weihong Tan +11 more
TL;DR: In this article, a de novo strategy was proposed to construct an antidiffusion probe by integrating a fluorochrome characterized by strong hydrophobicity and low lipophilicity, with an enzyme substrate to meet this challenge.
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In vivo imaging of alkaline phosphatase in tumor-bearing mouse model by a promising near-infrared fluorescent probe
TL;DR: A near-infrared (NIR) fluorescent probe (NALP) is reported for turn-on trapping of ALP activity in living cancer cells and tumors and applied for fluorescence imaging of ALP in tumor tissues and living tumor xenograft in nude mice for the first time.
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