Ke Lan
Sichuan University
40 Papers
280 Citations
Ke Lan is an academic researcher from Sichuan University. The author has contributed to research in topics: Chemistry & Bile acid. The author has an hindex of 16, co-authored 38 publications. Previous affiliations of Ke Lan include University of Hawaii.
Chat about Author
Papers
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism.
Xiaojiao Zheng,Tianlu Chen,Runqiu Jiang,Aihua Zhao,Qing Wu,Junliang Kuang,Dongnan Sun,Zhenxing Ren,Mengci Li,Mingliang Zhao,Shouli Wang,Yuqian Bao,Huating Li,Cheng Hu,Bing Dong,Defa Li,Jiayu Wu,Jialin Xia,Xuemei Wang,Ke Lan,Cynthia Rajani,Guoxiang Xie,Aiping Lu,Weiping Jia,Changtao Jiang,Wei Jia,Wei Jia,Wei Jia +27 more
TL;DR: It is confirmed in a clinical cohort, that lower serum concentrations of HCA species were associated with diabetes and closely related to glycemic markers.
282
An Integrated Metabolomics and Pharmacokinetics Strategy for Multi-Component Drugs Evaluation
TL;DR: The current progress of metabolomics based PK studies is reviewed, the potentials and challenges of such a strategy for herbal medicines are presented, and the future of the role of metabolites in the relationship between PK, PD and TOX of herbal medicines is looked into.
63
Metabolic Fate of Tea Polyphenols in Humans
Guoxiang Xie,Aihua Zhao,Linjing Zhao,Tianlu Chen,Huiyuan Chen,Xin Qi,Xiaojiao Zheng,Yan Ni,Yu Cheng,Ke Lan,Chun Yao,Mingfeng Qiu,Wei Jia +12 more
TL;DR: This study demonstrates that the metabonomic strategy will enable us to integrate the overwhelming amount of metabolic end points as a systems' response to the absorption, metabolism, and disposition of a multicomponent botanical intervention system, leading to a direct elucidation of their mechanisms of action.
56
Quantitative determination of rosuvastatin in human plasma by ion pair liquid-liquid extraction using liquid chromatography with electrospray ionization tandem mass spectrometry.
TL;DR: The assay was successfully applied to the analysis of rosuvastatin in human plasma samples derived from clinical pre-trials and indicated that the lower limit of quantification (LLOQ) was 0.1 ng mL(-1) and the assay exhibited a linear range of 0.8% at all tested concentration levels.
54
Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids
Ke Lan,Mingming Su,Guoxiang Xie,Brian C. Ferslew,Kim L. R. Brouwer,Cynthia Rajani,Changxiao Liu,Wei Jia +7 more
TL;DR: A novel BA, 3β,7β,12α-trihydroxy-5β-cholanic acid, was identified in the postprandial urine samples of patients with nonalcoholic steatohepatitis and may contribute to a better understanding of the chemical diversity of BAs and the molecular basis of human liver diseases that involve BA synthesis, transport, and metabolism.
53