Ke-Jun Han
Anschutz Medical Campus
9 Papers
270 Citations
Ke-Jun Han is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Transcription factor & TRIF. The author has an hindex of 8, co-authored 8 publications.
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Papers
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
TL;DR: Depletion of VISA inhibits virus-triggered and RIG-I-mediated activation of IRF-3, NF-kappaB, and the IFN-beta promoter, suggesting that VISA plays a central role in virus- Triggered TLR3-independent IFn-beta signaling.
1.8K
Mechanisms of the TRIF-induced Interferon-stimulated Response Element and NF-κB Activation and Apoptosis Pathways
TL;DR: The results suggest that the TRIF-induced IFN-stimulated response element and NF-κB activation and apoptosis pathways are uncoupled and provide a molecular explanation for the divergent effects induced by the adapter protein TRIF.
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The Ret Finger Protein Inhibits Signaling Mediated by the Noncanonical and Canonical IκB Kinase Family Members
Jikun Zha,Ke-Jun Han,Liang-Guo Xu,Wei He,Qianhe Zhou,Danying Chen,Zhonghe Zhai,Hong-Bing Shu +7 more
TL;DR: RFP negatively regulates signaling involved in the antiviral response and inflammation by targeting the IKKs, and knockdown of RFP expression by RNA interference-enhanced activation of IFN-stimulated response element and/or NF-κB triggered by polyinosinic-polycytidylic acid, TNF, and IL-1.
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Analysis of a TIR-less Splice Variant of TRIF Reveals an Unexpected Mechanism of TLR3-mediated Signaling
TL;DR: This study identified a splice variant of TRIF lacking the TIR domain, which is designated as TRIS and demonstrated that TRIS was associated with TRIF upon TLR3 activation by poly(I-C), revealing an unexpected mechanism ofTLR3-mediated signaling.
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Identification of a ZU5 and Death Domain-containing Inhibitor of NF-κB
TL;DR: The findings suggest that ZUD is an inhibitor of NF-κB activation and that this protein may provide an alternative regulatory mechanism for NF-σκB-mediated transcription.
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