5 Papers
Ke Chen is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Regulation of gene expression & Circular RNA. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Ke Chen include University of Illinois at Chicago.
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Papers
CSCD: a database for cancer-specific circular RNAs
Siyu Xia,Jing Feng,Ke Chen,Yanbing Ma,Jing Gong,Fangfang Cai,Yuxuan Jin,Yang Gao,Linjian Xia,Hong Chang,Lei Wei,Leng Han,Chunjiang He +12 more
TL;DR: A cancer-specific circRNA database is constructed (CSCD) that could significantly contribute to the research for the function and regulation of cancer-associated circRNAs.
CircRNA inhibits DNA damage repair by interacting with host gene
Xiaolong Xu,Jingwei Zhang,Yihao Tian,Yang Gao,Xin Dong,Wenbo Chen,Xiaoning Yuan,Weinan Yin,Jinjing Xu,Ke Chen,Chunjiang He,Chunjiang He,Lei Wei +12 more
TL;DR: It is demonstrated that circSMARCA5 can bind to its parent gene locus, forming an R-loop, which results in transcriptional pausing at exon 15 of SMarCA5, which revealed a new regulatory mechanism for circRNA on its host gene and provided evidence that circ SMAR CA5 may serve as a therapeutic target for drug-resistant breast cancer patients.
Genome-wide identification of cancer-specific alternative splicing in circRNA.
Jing Feng,Ke Chen,Xin Dong,Xiaolong Xu,Yuxuan Jin,Xinyang Zhang,Wenbo Chen,Yujing Han,Lin Shao,Yang Gao,Chunjiang He +10 more
TL;DR: This study presents the first comprehensive view of cancer-specific circRNA alternative splicing, which could contribute significantly to regulation and functional research of circRNAs in cancers.
YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation.
Jiong Li,Ke Chen,Xin Dong,Ya-Ting Xu,Qi Sun,Honghong Wang,Zhen Chen,Cong Liu,Rong Liu,Zhe Yang,Xiangfei Mei,Rongyu Zhang,Liuping Chang,Zongwen Tian,Jianjun Chen,Kaiwei Liang,Chunjiang He,Mengcheng Luo +17 more
TL;DR: Zhang et al. as mentioned in this paper found that deletion of YTHDF1 led to massive RNA patches deposited in the cytoplasm, which promoted P-body formation through liquid-liquid phase separation.
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Genome-wide characterization of lncRNAs in acute myeloid leukemia.
Lijun Lei,Siyu Xia,Dan Liu,Xiaoqing Li,Jing Feng,Yaqi Zhu,Jun Hu,Linjian Xia,Lieping Guo,Fei Chen,Hui Cheng,Ke Chen,Hanyang Hu,Xiaohua Chen,Feng Li,Shan Zhong,Nupur Mittal,Guohua Yang,Zhijian Qian,Leng Han,Chunjiang He +20 more
TL;DR: Of the identified lncRNAs, it is found that high expression level lncRNA LOC285758 is associated with the poor prognosis in AML patients and regulates proliferation of AML cell lines by enhancing the expression of HDAC2, a key factor in carcinogenesis.