Kazuhiro Sakurada
Keio University
24 Papers
198 Citations
Kazuhiro Sakurada is an academic researcher from Keio University. The author has contributed to research in topics: Stem cell & Gene. The author has an hindex of 7, co-authored 24 publications.
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Papers
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Keisuke Ito,Atsushi Hirao,Fumio Arai,Sahoko Matsuoka,Keiyo Takubo,Isao Hamaguchi,Kana Nomiyama,Kentaro Hosokawa,Kazuhiro Sakurada,Naomi Nakagata,Yasuo Ikeda,Tak W. Mak,Toshio Suda +12 more
TL;DR: It is shown that ATM has an essential function in the reconstitutive capacity of haematopoietic stem cells (HSCs) but is not as important for the proliferation or differentiation of progenitors, in a telomere-independent manner.
1.2K
Patent
Cell having the potentiality of differentiation into cardiomyocytes
Akihiro Umezawa,Jun-ichi Hata,Keiichi Fukuda,Satoshi Ogawa,Kazuhiro Sakurada,Satoshi Gojo,Yoji Yamada +6 more
- 28 Dec 2000
TL;DR: The present invention relates to methods for isolation, purification, expansion, and differentiation of cells having the potential to differentiate into cardiomyocytes using various cytokines and transcription factors as discussed by the authors.
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Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 undergo the stochastic cardiomyogenic fate and behave like transient amplifying cells
TL;DR: It is demonstrated that cardiomyocytes are generated stochastically from a single-cell-derived stem cell, and that overexpression of Csx/Nkx2.5 and GATA4 behaved like cardiac transient amplifying cells, and still retained their plasticity in vivo.
43
Patent
Cells capable of differentiating into heart muscle cells
Akihiro Umezawa,Jun-Ichi Hata,Keiichi Fukuda,Satoshi Ogawa,Kazuhiro Sakurada,Satoshi Gojo,Yoji Yamada +6 more
- 27 Dec 2000
TL;DR: In this article, the authors present methods of isolating, purifying, culturing, and differentiation-inducing cells which are capable of differentiating into heart muscle cells using various cytokines, transcriptional factors, etc.
40
Patent
Novel adult tissue-derived stem cell and use thereof
Toshio Suda,Atsushi Hirao,Fumio Arai,Kazuhiro Sakurada,Yoji Yamada,Hiroshi Ando,Hidetaka Sato,Hiromi Yokoyama,Masahiko Ishihara +8 more
- 14 May 2004
TL;DR: In this article, a technology for separating, isolating and culturing a stem cell derived from adult tissue while retaining the in vivo properties thereof, and to provide a preventive and/or therapeutic agent for diseases which accompany tissue injury.
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