Kazuhiko Koike
University of Tokyo
1209 Papers
8.6K Citations
Kazuhiko Koike is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Hepatocellular carcinoma. The author has an hindex of 79, co-authored 1157 publications. Previous affiliations of Kazuhiko Koike include Jikei University School of Medicine & Japanese Foundation for Cancer Research.
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Papers
Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.
Hayato Nakagawa,Nobumi Suzuki,Yoshihiro Hirata,Yohko Hikiba,Yoku Hayakawa,Hiroto Kinoshita,Sozaburo Ihara,Koji Uchino,Yuji Nishikawa,Hideaki Ijichi,Motoyuki Otsuka,Junichi Arita,Yoshihiro Sakamoto,Kiyoshi Hasegawa,Norihiro Kokudo,Keisuke Tateishi,Kazuhiko Koike +16 more
TL;DR: It is demonstrated that a biliary epithelial injury-induced regenerative response mediated by IL-33 accelerates development of extrahepatic cholangiocarcinoma from peribiliary glands, an effect that was suppressed by anti–IL-33 treatment.
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Trend and Risk Factors of Diverticulosis in Japan: Age, Gender, and Lifestyle/Metabolic-Related Factors May Cooperatively Affect on the Colorectal Diverticula Formation
Nobutake Yamamichi,Takeshi Shimamoto,Yu Takahashi,Yoshiki Sakaguchi,Hikaru Kakimoto,Rie Matsuda,Yosuke Kataoka,Itaru Saito,Yosuke Tsuji,Seiichi Yakabi,Chihiro Takeuchi,Chihiro Minatsuki,Keiko Niimi,Itsuko Asada-Hirayama,Chiemi Nakayama,Satoshi Ono,Shinya Kodashima,Daisuke Yamaguchi,Mitsuhiro Fujishiro,Yutaka Yamaji,Ryoichi Wada,Toru Mitsushima,Kazuhiko Koike +22 more
TL;DR: The large-scale data of asymptomatic colonoscopy examinees from the general population from 1990 to 2010 indicated that the prevalence of diverticulosis is still increasing in Japan.
Increase in the concentration of carbon 18 monounsaturated fatty acids in the liver with hepatitis C: analysis in transgenic mice and humans.
Kyoji Moriya,Toru Todoroki,Takeya Tsutsumi,Takeya Tsutsumi,Hajime Fujie,Yoshizumi Shintani,Hideyuki Miyoshi,Kotaro Ishibashi,Tadatoshi Takayama,Masatoshi Makuuchi,Kiyoaki Watanabe,Tatsuo Miyamura,Satoshi Kimura,Kazuhiko Koike +13 more
TL;DR: The results suggest that HCV may affect a specific pathway in the lipid metabolism and cause steatosis in the liver.
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Idiopathic retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pericarditis—Retrospective analysis of 11 case histories
Aiko Sakamoto,Ryozo Nagai,Kan Saito,Yasushi Imai,Masao Takahashi,Yumiko Hosoya,Norifumi Takeda,Kenji Hirano,Kazuhiko Koike,Yutaka Enomoto,Haruki Kume,Yukio Homma,Daichi Maeda,Hideomi Yamada,Masashi Fukayama,Yasunobu Hirata,Nobukazu Ishizaka,Nobukazu Ishizaka +17 more
TL;DR: The notion that immune-inflammatory mechanism, which might be IgG4-related sometimes, may play a role in idiopathic retroperitoneal fibrosis, inflammatory aortic aneurysm, and mediastinal/pericardial fibrosis is supported, although clinical course may differ substantially.
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A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion.
Tsuneo Ikenoue,Yumi Terakado,Hayato Nakagawa,Yohko Hikiba,Tomoaki Fujii,Daisuke Matsubara,Rei Noguchi,Chi Zhu,Keisuke Yamamoto,Yotaro Kudo,Yoshinari Asaoka,Kiyoshi Yamaguchi,Hideaki Ijichi,Keisuke Tateishi,Noriyoshi Fukushima,Shin Maeda,Kazuhiko Koike,Yoichi Furukawa +17 more
TL;DR: The data suggest that mice carrying liver-specific Kras activation in combination with homozygous Pten deletion should be useful for the investigation of therapeutic strategies for human ICC.