Kazuhiko Koike
University of Tokyo
1209 Papers
8.6K Citations
Kazuhiko Koike is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Hepatocellular carcinoma. The author has an hindex of 79, co-authored 1157 publications. Previous affiliations of Kazuhiko Koike include Jikei University School of Medicine & Japanese Foundation for Cancer Research.
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Papers
Use of Antibiotics and Probiotics Reduces the Risk of Metachronous Gastric Cancer after Endoscopic Resection.
Junya Arai,Ryota Niikura,Ryota Niikura,Yoku Hayakawa,Takuya Kawahara,Tetsuro Honda,Kenkei Hasatani,Naohiro Yoshida,Tsutomu Nishida,Tetsuya Sumiyoshi,Shu Kiyotoki,Takashi Ikeya,Masahiro Arai,Nobumi Suzuki,Yosuke Tsuji,Atsuo Yamada,Takashi Kawai,Kazuhiko Koike +17 more
TL;DR: In this paper, a multicenter retrospective cohort study was conducted with data from nine hospital databases on patients who underwent endoscopic resection for gastric cancer between 2014 and 2019 to evaluate the association between medication use and the incidence of metachronous Gastric cancer after endoscopy.
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ORIGINAL ARTICLES—LIVER, PANCREAS, AND BILIARY TRACT Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma
Kohichiroh Yasui,Etsuko Hashimoto,Yasuji Komorizono,Kazuhiko Koike,Shigeki Arii,Y. Imai,Toshihide Shima,Yoshihiro Kanbara,Toshiji Saibara,Takahiro Mori,Sumio Kawata,Hirofumi Uto,Shiro Takami,Yoshio Sumida,Toshinari Takamura,Miwa Kawanaka,Takeshi Okanoue +16 more
- 01 Jan 2011
TL;DR: In this paper, the clinical features of NASH patients with hepatocellular carcinoma (HCC) were characterized in a cross-sectional multicenter study in Japan, where 87 patients with histologically proven NASH who developed HCC were examined.
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Tacrolimus Ameliorates Metabolic Disturbance and Oxidative Stress Caused by Hepatitis C Virus Core Protein: Analysis Using Mouse Model and Cultured Cells
Kyoji Moriya,Hideyuki Miyoshi,Takeya Tsutsumi,Seiko Shinzawa,Hajime Fujie,Yoshizumi Shintani,Hiroshi Yotsuyanagi,Kohji Moriishi,Yoshiharu Matsuura,Tetsuro Suzuki,Tatsuo Miyamura,Kazuhiko Koike +11 more
TL;DR: Tacrolimus reversed the effect of the core protein in the pathogenesis of HCV-associated liver disease, which may provide new therapeutic tools for chronic hepatitis C, in which oxidative stress and abnormalities in lipid and glucose metabolism contribute to liver pathogenesis.
RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis.
Akemi Takata,Motoyuki Otsuka,Takahiro Kishikawa,Mari Yamagami,Rei Ishibashi,Kazuma Sekiba,Tatsunori Suzuki,Motoko Ohno,Yui Yamashita,Takaya Abe,Ryota Masuzaki,Tsuneo Ikenoue,Kazuhiko Koike +12 more
TL;DR: It is demonstrated that deregulated RASAL1 expression levels and the affected downstream intracellular signaling are central mediators of perpetuated HSC activation and fibrogenesis in the liver.
Perihepatic lymph node enlargement is a negative predictor of liver cancer development in chronic hepatitis C patients.
Hiromi Hikita,Hayato Nakagawa,Ryosuke Tateishi,Ryota Masuzaki,Kenichiro Enooku,Haruhiko Yoshida,Masao Omata,Yoko Soroida,Mamiko Sato,Hiroaki Gotoh,Atsushi Suzuki,Tomomi Iwai,Hiromitsu Yokota,Kazuhiko Koike,Yutaka Yatomi,Hitoshi Ikeda +15 more
TL;DR: Patients withPLNE had a lower risk of HCC development than those without PLNE, and the sustained viral response rate in patients who received interferon (IFN) therapy was significantly lower in patients with PLNE than in patients withoutPLNE.
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