Kazuhiko Ino
Wakayama Medical University
195 Papers
1.8K Citations
Kazuhiko Ino is an academic researcher from Wakayama Medical University. The author has contributed to research in topics: Medicine & Ovarian cancer. The author has an hindex of 39, co-authored 189 publications. Previous affiliations of Kazuhiko Ino include Nagoya University.
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Papers
Gene silencing of glypican-3 in clear cell carcinoma of the ovary renders it more sensitive to the apoptotic agent paclitaxel in vitro and in vivo.
Tomokazu Umezu,Kiyosumi Shibata,Maiko Shimaoka,Hiroaki Kajiyama,Eiko Yamamoto,Kazuhiko Ino,Akihiro Nawa,Takeshi Senga,Fumitaka Kikkawa +8 more
TL;DR: The results indicate that increased GPC3 expression in a clear cell carcinoma cell line may play a protective role against apoptosis, and so the downregulation of G PC3 may be a potential target to increase sensitivity to paclitaxel‐induced apoptosis in clearcell carcinoma.
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Cytoplasmic p53 aggregates accumulated in p53-mutated cancer correlate with poor prognosis
Naoyuki Iwahashi,Midori Ikezaki,Yoshihiro Komohara,Yukio Fujiwara,Tomoko Noguchi,Kaho Nishioka,Kazuko Sakai,Kazuto Nishio,Mitsuharu Ueda,Yoshito Ihara,Kenji Uchimura,Kazuhiko Ino,Kazuchika Nishitsuji +12 more
TL;DR: The involvement of p53 aggregate transmission in poor prognosis and in chemotherapy resistance in cancers is indicated by screening patients with high-grade serous ovarian carcinoma.
Eradicative brachytherapy with hyaluronate gel injection into pararectal space in treatment of bulky vaginal stump recurrence of uterine cancer
Kazushi Kishi,Yasushi Mabuchi,Tetsuo Sonomura,Shintaro Shirai,Yasutaka Noda,Morio Sato,Kazuhiko Ino +6 more
TL;DR: Brachytherapy with a pararectal gel injection can be a safe and effective eradicative option for bulky vaginal stump recurrence of uterine cancer without risk of damaging surrounding organs.
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Enhanced cytotoxicity with a novel system combining the paclitaxel-2'-ethylcarbonate prodrug and an HSV amplicon with an attenuated replication-competent virus, HF10 as a helper virus.
Daisuke Ishida,Akihiro Nawa,Tadatoshi Tanino,Fumi Goshima,Chen Hong Luo,Masahiro Iwaki,Hiroaki Kajiyama,Kiyosumi Shibata,Eiko Yamamoto,Kazuhiko Ino,Tatsuya Tsurumi,Yukihiro Nishiyama,Fumitaka Kikkawa +12 more
TL;DR: In this paper, the authors investigated the efficacy of gene-directed enzyme prodrug therapy (GDEPT) using a novel system that combines the paclitaxel-2'-ethylcarbonate prodrug (TAX-2]-Et) and an HSV amplicon expressing rabbit-carboxylesterase (CES) with HF10 as a helper virus.
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Tumoricidal effect of human macrophage-colony-stimulating factor against human-ovarian-carcinoma-bearing athymic mice and its therapeutic effect when combined with cisplatin
Toshio Adachi,Hisao Mano,Yutaka Shinohara,Toru Nakanishi,Takanobu Suzuki,Kazuhiko Ino,Noriko Kato,Tomomitsu Okamoto,Akihiro Nawa,Setsuko Goto,Yutaka Tomoda +10 more
TL;DR: The data demonstrate that hM-CSF administered i.p. has a tumoricidal activity in athymic mice bearing human ovarian cancer i.
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