Kazuaki Shimada
Tokyo Medical and Dental University
297 Papers
1.7K Citations
Kazuaki Shimada is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Medicine & Hepatectomy. The author has an hindex of 56, co-authored 263 publications.
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Papers
Genomic spectra of biliary tract cancer
Hiromi Nakamura,Yasuhito Arai,Yasushi Totoki,Tomoki Shirota,Asmaa Elzawahry,Mamoru Kato,Natsuko Hama,Fumie Hosoda,Tomoko Urushidate,Shoko Ohashi,Nobuyoshi Hiraoka,Hidenori Ojima,Kazuaki Shimada,Takuji Okusaka,Tomoo Kosuge,Shinichi Miyagawa,Tatsuhiro Shibata +16 more
TL;DR: The subgroup with the poorest prognosis had significant enrichment of hypermutated tumors and a characteristic elevation in the expression of immune checkpoint molecules, suggesting immune-modulating therapies might also be potentially promising options for these patients.
1.1K
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
Akihiro Fujimoto,Yasushi Totoki,Tetsuo Abe,Keith A. Boroevich,Fumie Hosoda,Ha Hai Nguyen,Masayuki Aoki,Naoya Hosono,Michiaki Kubo,Fuyuki Miya,Yasuhito Arai,Hiroyuki Takahashi,Takuya Shirakihara,Masao Nagasaki,Tetsuo Shibuya,Kaoru Nakano,Kumiko Watanabe-Makino,Hiroko Tanaka,Hiromi Nakamura,Jun Kusuda,Hidenori Ojima,Kazuaki Shimada,Takuji Okusaka,Masaki Ueno,Yoshinobu Shigekawa,Yoshiiku Kawakami,Koji Arihiro,Hideki Ohdan,Kunihito Gotoh,Osamu Ishikawa,Shunichi Ariizumi,Masakazu Yamamoto,Terumasa Yamada,Kazuaki Chayama,Tomoo Kosuge,Hiroki Yamaue,Naoyuki Kamatani,Satoru Miyano,Hitoshi Nakagama,Yusuke Nakamura,Tatsuhiko Tsunoda,Tatsuhiro Shibata,Hidewaki Nakagawa +42 more
TL;DR: The whole-genome sequencing analysis of HCCs identified the influence of etiological background on somatic mutation patterns and subsequent carcinogenesis, as well as recurrent mutations in chromatin regulators in H CCs.
890
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
Yasushi Totoki,Kenji Tatsuno,Kyle R. Covington,Hiroki R. Ueda,Chad J. Creighton,Mamoru Kato,Shingo Tsuji,Lawrence A. Donehower,Betty L. Slagle,Hiromi Nakamura,Shogo Yamamoto,Eve Shinbrot,Natsuko Hama,Megan Lehmkuhl,Fumie Hosoda,Yasuhito Arai,Kim Walker,Mahmoud Dahdouli,Kengo Gotoh,Genta Nagae,Marie-Claude Gingras,Donna M. Muzny,Hidenori Ojima,Kazuaki Shimada,Yutaka Midorikawa,John A. Goss,Ronald T. Cotton,Akimasa Hayashi,Junji Shibahara,Shumpei Ishikawa,Jacfranz J. Guiteau,Mariko Tanaka,Tomoko Urushidate,Shoko Ohashi,Naoko Okada,Harsha Doddapaneni,Min Wang,Yiming Zhu,Huyen Dinh,Takuji Okusaka,Norihiro Kokudo,Tomoo Kosuge,Tadatoshi Takayama,Masashi Fukayama,Richard A. Gibbs,David A. Wheeler,Hiroyuki Aburatani,Tatsuhiro Shibata +47 more
TL;DR: A combination of hotspot TERT promoter mutation, TERT focal amplification and viral genome integration occurs in more than 68% of cases, implicating TERT as a central and ancestry-independent node of hepatocarcinogenesis.
717
Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma
Yasuhito Arai,Yasushi Totoki,Fumie Hosoda,Tomoki Shirota,Natsuko Hama,Hiromi Nakamura,Hidenori Ojima,Koh Furuta,Kazuaki Shimada,Takuji Okusaka,Tomoo Kosuge,Tatsuhiro Shibata +11 more
TL;DR: The expression pattern of these fusions in association with sensitivity to FGFR inhibitors warrant a new molecular classification of cholangiocarcinoma and suggest a new therapeutic approach to the disease.
503
Early hepatocellular carcinoma as an entity with a high rate of surgical cure
Tadatoshi Takayama,Masatoshi Makuuchi,Setsuo Hirohashi,Michiie Sakamoto,Junji Yamamoto,Kazuaki Shimada,Tomoo Kosuge,Shuichi Okada,Kenichi Takayasu,Susumu Yamasaki +9 more
TL;DR: Early HCC is a distinct clinical entity with a high rate of surgical cure, thereby justifying its definition, and can be a lesion that corresponds to “Stage 0” cancer in other organs.
398