Kay Sauder
University of Michigan
14 Papers
59 Citations
Kay Sauder is an academic researcher from University of Michigan. The author has contributed to research in topics: Medicine & Fibrosis. The author has an hindex of 10, co-authored 14 publications.
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Papers
Matrix Stiffness Corresponding to Strictured Bowel Induces a Fibrogenic Response in Human Colonic Fibroblasts
Laura A. Johnson,Eva S. Rodansky,Kay Sauder,Jeffrey C. Horowitz,Justin D. Mih,Daniel J. Tschumperlin,Peter D.R. Higgins +6 more
TL;DR: Matrix stiffness, representative of the pathologic stiffness of Crohn’s strictures, activates human colonic fibroblasts to a fibrogenic phenotype, suggesting that the mechanical properties of the cellular environment are critical to fibroblast function and may contribute to auto-propagation of intestinal fibrosis in the absence of inflammation.
Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: impact of a "Top-Down" approach to intestinal fibrosis in mice.
TL;DR: It is demonstrated that intestinal fibrosis develops despite removal of an inflammatory stimulus and elimination of inflammation, suggesting that fibrosis, once initiated, is self‐propagating, and that a very early top‐down interventional approach may have the most impact on fibrostenosing disease.
Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestine.
Peter D.R. Higgins,Laura A. Johnson,Jay Luther,Min Zhang,Kay Sauder,Luz P. Blanco,John Y. Kao +6 more
TL;DR: A potential mechanism for the negative association between H. pylori and IBD in humans is demonstrated by repressing the lower gastrointestinal tract Th17 response to bacterially induced colitis via extragastric immunomodulatory effects, illustrating immunological crosstalk between the upper andLower gastrointestinal tract.
Development and Validation of Machine Learning Models in Prediction of Remission in Patients With Moderate to Severe Crohn Disease
Akbar K. Waljee,Beth I Wallace,Shirley Cohen-Mekelburg,Yumu Liu,Boang Liu,Kay Sauder,Ryan W. Stidham,Ji Zhu,Peter D.R. Higgins +8 more
- 03 May 2019
TL;DR: Long-term ustekinumab response may be predicted using demographic and laboratory data before week 8 of treatment, without the need for costly drug-level monitoring.
Machine learning algorithms for objective remission and clinical outcomes with thiopurines
Akbar K. Waljee,Akbar K. Waljee,Kay Sauder,Anand Patel,Sandeep Segar,Boang Liu,Yiwei Zhang,Ji Zhu,Ryan W. Stidham,Ulysses J. Balis,Peter D.R. Higgins +10 more
TL;DR: A machine learning algorithm was able to identify IBD patients on thiopurines with algorithm-predicted objective remission, a state associated with significant clinical benefits, including decreased steroid prescriptions, hospitalisations, and surgeries.
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