Kavya Annu
St. Jude Children's Research Hospital
7 Papers
Kavya Annu is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Vitamin D and neurology & Pregnane X receptor. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Kavya Annu include University of Tennessee Health Science Center.
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Papers
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
Ian R. A. Mackenzie,Alexandra M. Nicholson,Mohona Sarkar,James Messing,Maria D. Purice,Cyril Pottier,Kavya Annu,Matt Baker,Ralph B. Perkerson,Aishe Kurti,Billie J. Matchett,Tanja Mittag,Jamshid Temirov,Ging-Yuek Robin Hsiung,Charles Krieger,Charles Krieger,Melissa E. Murray,Masato Kato,John D. Fryer,Leonard Petrucelli,Lorne Zinman,Sandra Weintraub,M.-Marsel Mesulam,Julia Keith,Sasha Zivkovic,Veronica Hirsch-Reinshagen,Raymond P. Roos,Stephan Züchner,Neill R. Graff-Radford,Ronald C. Petersen,Richard J. Caselli,Zbigniew K. Wszolek,Elizabeth Finger,Carol F. Lippa,Carol F. Lippa,David Lacomis,Heather Stewart,Dennis W. Dickson,Hong Joo Kim,Ekaterina Rogaeva,Eileen H. Bigio,Kevin B. Boylan,J. Paul Taylor,Rosa Rademakers +43 more
TL;DR: The identification of TIA1 mutations in ALS/FTD reinforces the importance of RNA metabolism and SG dynamics in ALS-FTD pathogenesis.
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Accurate genomic variant detection in single cells with primary template-directed amplification.
Veronica Gonzalez-Pena,Veronica Gonzalez-Pena,Sivaraman Natarajan,Yuntao Xia,David C. Klein,Robert A. Carter,Yakun Pang,Yakun Pang,Bridget Shaner,Kavya Annu,Daniel Putnam,Wenan Chen,Jon P. Connelly,Shondra M. Pruett-Miller,Xiang Chen,John Easton,Charles Gawad +16 more
TL;DR: In this paper, the primary template-directed amplification (PTA) method was used for genome-wide off-target indel and structural variant detection in cells that had undergone CRISPR-mediated genome editing, establishing the feasibility for performing single-cell evaluations of biopsies from edited tissues.
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Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation
Monicah Bwayi,Efrén García-Maldonado,Sergio C. Chai,Boer Xie,Shirish Chodankar,Andrew D. Huber,Jing Wu,Kavya Annu,William C. Wright,Hyeong-Min Lee,Jayaraman Seetharaman,Jingheng Wang,Cameron D. Buchman,Junmin Peng,Taosheng Chen +14 more
TL;DR: The molecular basis of crosstalk between the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), where they form a novel heterodimer, resulting in their mutual inhibition, is reported.
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Design and Optimization of 1H-1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR.
Yongtao Li,Wenwei Lin,Sergio C. Chai,Jing Wu,Kavya Annu,Taosheng Chen +5 more
TL;DR: In this article , a series of 1H-1,2,3-triazole-4-carboxamides compounds were optimized to achieve low nanomolar IC50 values for binding and cellular activity.
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Vitamin D levels do not cause vitamin-drug interactions with dexamethasone or dasatinib in mice
TL;DR: In this paper, the effect of VD3 status on DEX systemic exposure was compared following a discontinuous oral DEX regimen, similar to that used to treat pediatric acute lymphoblastic leukemia patients.