Katrin Luckert
University of Tübingen
7 Papers
26 Citations
Katrin Luckert is an academic researcher from University of Tübingen. The author has contributed to research in topics: Wnt signaling pathway & Catenin. The author has an hindex of 5, co-authored 7 publications.
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Papers
Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia
Evgeny A. Moskalev,Katrin Luckert,Ivan A. Vorobjev,Ivan A. Vorobjev,Sergey E. Mastitsky,Aleena Gladkikh,Achim Stephan,Marita Schrenk,K D Kaplanov,Olga B. Kalashnikova,Oliver Pötz,Thomas O. Joos,Jörg D. Hoheisel +12 more
TL;DR: An epigenetic silencing mechanism of the Wnt/β-catenin pathway inhibitor genes in CLL is suggested, which may result from the tumour epigenome reprogramming orchestrated by Polycomb-group repressive complexes.
Representing dynamic biological networks with multi-scale probabilistic models.
Alexander Groß,Barbara Kracher,Johann M. Kraus,Silke D. Kühlwein,Astrid S. Pfister,Sebastian Wiese,Katrin Luckert,Oliver Pötz,Thomas O. Joos,Dries Van Daele,Luc De Raedt,Michael Kühl,Hans A. Kestler +12 more
- 17 Jan 2019
TL;DR: This work proposes a new approach, ProbRules, that combines probabilities and logical rules to represent the dynamics of a system across multiple scales, and demonstrates that ProbRules models can represent various network motifs of biological systems.
A Dual Array-Based Approach to Assess the Abundance and Posttranslational Modification State of Signaling Proteins
Katrin Luckert,Taranjit S. Gujral,Marina Chan,Mark Sevecka,Thomas O. Joos,Peter K. Sorger,Gavin MacBeath,Oliver Pötz +7 more
TL;DR: A bead-based array and its use in characterizing the different forms and functions of β-catenin, as well as lysate microarrays and their use in detecting and quantifying proteins involved in the canonical and noncanonical Wnt signaling pathways are described.
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Snapshots of Protein Dynamics and Post-translational Modifications In One Experiment—β-Catenin and Its Functions
TL;DR: This study demonstrates an increase in β-catenin phosphorylated at Ser-45 upon treatment of cells with rWnt3a or a GSK3 inhibition and links C-terminal phosphorylation of β- catenin on Ser-552 and Ser-675 with canonical Wnt signaling.
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Microsphere-based co-immunoprecipitation in multiplex.
TL;DR: Catenin-cadherin complexes were employed to establish a multiplexed microsphere-based co-immunoprecipitation (micro co-IP) protocol that allows the analysis of different complexes of a given protein with various interacting proteins within a single experiment using a limited amount of sample material.
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