Katrin K. Fleischmann
Ludwig Maximilian University of Munich
5 Papers
14 Citations
Katrin K. Fleischmann is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Fusion gene & Gene knockdown. The author has an hindex of 4, co-authored 5 publications.
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Papers
The leukemogenic fusion gene MLL-AF9 alters microRNA expression pattern and inhibits monoblastic differentiation via miR- 511 repression
Katrin K. Fleischmann,Philipp Pagel,Julia von Frowein,Thomas Magg,Adelbert A. Roscher,Irene Schmid +5 more
TL;DR: This study identified one of the most intensely repressed miRNAs, miR-511, to raise CCL2 expression, directly target cyclin D1, inhibit cell cycle progression, increase cellular migration and promote monoblastic differentiation, and may have a therapeutic potential as a pro-differentiation agent as well as in leukemia vaccination approaches.
Identification of microRNAs Involved in mTOR Nutrient Signaling during Adipocyte Differentiation
Theresa Kaeuferle,Andrea Osswald,Katrin K. Fleischmann,Philipp Pagel,Julia von Frowein,Susanne Krauss-Etschmann,Adelbert A. Roscher +6 more
TL;DR: A novel role for a set of miRNAs during adipocyte differentiation and mTOR signaling is revealed and their potential as biomarkers for nutrient-driven dysregulation of adipogenesis is suggested.
RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes.
TL;DR: Besides potential new therapeutic targets, the described transcription profile shaped by MLL-AF9 provides an information source into the molecular processes altered in MLL aberrant leukemia.
MiR-492 regulates metastatic properties of hepatoblastoma via CD44.
Julia von Frowein,Stefanie M. Hauck,Roland Kappler,Philipp Pagel,Katrin K. Fleischmann,Thomas Magg,Stefano Cairo,Adelbert A. Roscher,Dietrich von Schweinitz,Irene Schmid +9 more
TL;DR: It is aimed to identify malignant and metastasis promoting effects of miR‐492, a miRNA, previously reported to be overexpressed in metastatic hepatoblastoma and evaluate its diagnostic and prognostic potential.
MiRNome and transcriptome aided pathway analysis in human regulatory T cells
Michael H. Albert,J Mannert,Katrin K. Fleischmann,M Schiemann,Philipp Pagel,Irene Schmid,Thomas Magg +6 more
TL;DR: Analysis of resting and activated human Treg cells in comparison with non-regulatory conventional T cells revealed characteristic signal transduction pathways involved in Treg biology, and allowed for the prediction of specific pathway activities on the basis of miR and mRNA transcript levels in a probabilistic manner.