Katlyn Lederer
University of Pennsylvania
14 Papers
1 Citations
Katlyn Lederer is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Germinal center. The author has an hindex of 4, co-authored 5 publications.
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Papers
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Mohamad-Gabriel Alameh,István Tombácz,Emily Bettini,Katlyn Lederer,Chutamath Sittplangkoon,Joel R. Wilmore,Brian T. Gaudette,Ousamah Younoss Soliman,Matthew Pine,Philip Hicks,Tomaz B. Manzoni,James J. Knox,John L. Johnson,Dorottya Laczkó,Hiromi Muramatsu,Benjamin Davis,Wenzhao Meng,Aaron M. Rosenfeld,Shirin Strohmeier,Paulo J.C. Lin,Barbara L. Mui,Ying K. Tam,Katalin Karikó,Alain Jacquet,Florian Krammer,Paul Bates,Michael P. Cancro,Drew Weissman,Eline T. Luning Prak,David Allman,Michela Locci,Norbert Pardi +31 more
TL;DR: In this article, a lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines have shown great efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the mechanism of action of this vaccine platform is not well-characterized.
396
SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.
Katlyn Lederer,Diana Castaño,Diana Castaño,Daniela Gómez Atria,Thomas H. Oguin,Sidney Wang,Tomaz B. Manzoni,Hiromi Muramatsu,Michael J. Hogan,Fatima Amanat,Patrick Cherubin,Kendall A. Lundgreen,Ying K. Tam,Steven H.Y. Fan,Laurence C. Eisenlohr,Laurence C. Eisenlohr,Ivan Maillard,Drew Weissman,Paul Bates,Florian Krammer,Gregory D. Sempowski,Norbert Pardi,Michela Locci +22 more
TL;DR: Overall, this study identifies SARS-CoV-2 mRNA vaccines as strong candidates for promoting robust GC-derived immune responses and directly compared two vaccine platforms −mRNA vaccines and a recombinant protein formulated with an MF59-like adjuvant− for their ability to quantitatively and qualitatively shape Sars-Cov-2-specific primary GC responses over time.
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Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals
Katlyn Lederer,Emily Bettini,Kalpana Parvathaneni,Mark M. Painter,Divyansh Agarwal,Kendall A. Lundgreen,Madison E. Weirick,Kavitha Muralidharan,Diana Castaño,Rishi R. Goel,Xiaoming Xu,E. M. Drapeau,Sigrid Gouma,Jordan T. Ort,M. Awofolaju,Allison R. Greenplate,Carole Le Coz,Neil Romberg,Jennifer Trofe-Clark,Gregory Malat,Lisa Jones,Marc Rosen,Daniela Weiskopf,Alessandro Sette,Behdad Besharatian,M. Kamińiski,Scott E. Hensley,Paul Bates,E. John Wherry,Ali Naji,Vijay Bhoj,Michela Locci +31 more
TL;DR: In this paper , the immune responses to SARS-CoV-2 mRNA vaccines in lymph nodes of healthy individuals and kidney transplant recipients (KTXs) were analyzed through a fine-needle aspiration-based approach.
132
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Mohamad-Gabriel Alameh,István Tombácz,Emily Bettini,Katlyn Lederer,Chutamath Sittplangkoon,Joel R. Wilmore,Brian Gaudette,Ousamah Younoss Soliman,Matthew Pine,Philip Hicks,Tomaz B. Manzoni,James J. Knox,John L. Johnson,Dorottya Laczkó,Hiromi Muramatsu,Benjamin Davis,Wenzhao Meng,Aaron M. Rosenfeld,Shirin Strohmeier,Paulo J.C. Lin,Barbara L. Mui,Ying K. Tam,Katalin Karikó,Alain Jacquet,Florian Krammer,Paul Bates,Michael P. Cancro,Drew Weissman,Eline T. Luning Prak,David Allman,Michela Locci,Norbert Pardi +31 more
TL;DR: Alameh et al. as discussed by the authors corrected two authors who were omitted from the author list, and the author contribution section and the acknowledgments have been updated and corrected online and in print.
103
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals
Katlyn Lederer,Kalpana Parvathaneni,Mark M Painter,Emily Bettini,Divyansh Agarwal,Kendall A. Lundgreen,Madison E. Weirick,Rishi R. Goel,Xiaoming Xu,Elizabeth M Drapeau,Sigrid Gouma,Allison R. Greenplate,Carole Le Coz,Carole Le Coz,Neil Romberg,Neil Romberg,Lisa Jones,Mark A. Rosen,Behdad Besharatian,Mary Kaminiski,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Scott E. Hensley,Paul Bates,E. John Wherry,Ali Naji,Vijay Bhoj,Michela Locci +28 more
TL;DR: In this paper, the immune responses to SARS-CoV-2 mRNA vaccines in lymph nodes of healthy individuals and kidney transplant (KTX) recipients were profiled through a fine-needle-aspiration-based approach.