Katja Thaysen
University of Southern Denmark
7 Papers
Katja Thaysen is an academic researcher from University of Southern Denmark. The author has contributed to research in topics: Sterol & Sterol homeostasis. The author has an hindex of 1, co-authored 1 publications.
Chat about Author
Papers
Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
Mikael B. L. Winkler,Rune T. Kidmose,Maria Szomek,Katja Thaysen,Shaun Rawson,Stephen P. Muench,Daniel Wüstner,Bjørn Panyella Pedersen +7 more
TL;DR: A model for sterol integration is proposed that clarifies the role of NPC proteins in this essential eukaryotic pathway and that rationalizes mutations in patients with Niemann-Pick disease type C.
132
Direct Observation of Uptake and Dissolution of Cholesterol Crystals by Macrophages Using Combined Fluorescence and X-ray Microscopy.
Alice Dupont Juhl,Suzana Kozakijevic,Tido Willms,Jacob Marcus Egebjerg,Maria Szomek,Katja Thaysen,Christoph Pratsch,S. Werner,Gerd Schneider,Peter Müller,Daniel Wüstner +10 more
Automated quantification of vacuole fusion and lipophagy in Saccharomyces cerevisiae from fluorescence and cryo-soft X-ray microscopy data using deep learning.
Jacob Marcus Egebjerg,Maria Szomek,Katja Thaysen,Alice Dupont Juhl,Suzana Kozakijevic,Stephan Werner,Christoph Pratsch,Gerd Schneider,Sergey Kapishnikov,Axel Ekman,Richard Röttger,Daniel Wüstner +11 more
TL;DR: This work developed a convolutional neural network model which classifies fully fused versus partially fused vacuoles based on fluorescence images of stained cells and revealed that cells lacking Ncr1 (ncr1∆ cells) or Npc2 (npc2∆ Cells) have a reduced capacity for vacuole fusion.
Conformational changes in the Niemann-Pick type C1 protein NCR1 drive sterol translocation.
Kelly M. Frain,Emil Dedic,Lynette Nel,Anastasiia Bohush,Esben Olesen,Katja Thaysen,Daniel Wüstner,David L. Stokes,Bjørn Panyella Pedersen +8 more
TL;DR: A transport model suggests that NPC proteins work by a generalized RND mechanism where the proton motive force drives conformational changes in the transmembrane domains that are allosterically coupled to luminal/extracellular domains to promote sterol transport.