Katja Schuster
University of Texas Southwestern Medical Center
14 Papers
132 Citations
Katja Schuster is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Cancer & Genetically modified mouse. The author has an hindex of 10, co-authored 14 publications. Previous affiliations of Katja Schuster include St. Jude Children's Research Hospital & Martin Luther University of Halle-Wittenberg.
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Papers
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on Notch signaling
James P. Sullivan,Monica Spinola,Michael E. Dodge,Maria Gabriela Raso,Carmen Behrens,Boning Gao,Katja Schuster,Chunli Shao,Jill E. Larsen,Laura A. Sullivan,Sofia Honorio,Yang Xie,Pier Paolo Scaglioni,J. Michael DiMaio,Adi F. Gazdar,Jerry W. Shay,Ignacio I. Wistuba,John D. Minna +17 more
TL;DR: Findings indicate that ALDH selects for a subpopulation of self-renewing NSCLC stem-like cells with increased tumorigenic potential, that NSCLCs harboring tumor cells with ALDH1A1 expression have inferior prognosis, and that AL DH 1A1 and CD133 identify different tumor subpopulations.
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Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non–Small Cell Lung Cancer Harboring K-RAS Mutations
Georgia Konstantinidou,Erik A. Bey,Andrea Rabellino,Katja Schuster,Michael S. Maira,Adi F. Gazdar,Augusto Amici,David A. Boothman,Pier Paolo Scaglioni +8 more
TL;DR: It is found that dual PI3K/mTOR blockade effectively sensitizes NSCLC expressing oncogenic K-RAS to the proapoptotic effects of IR both in vitro and in vivo.
Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib
Disha Dumka,Poonam Puri,Nathalie Carayol,Nathalie Carayol,Crystal Lumby,Harikrishnan Balachandran,Katja Schuster,Amit Verma,Lance S. Terada,Leonidas C. Platanias,Leonidas C. Platanias,Simrit Parmar +11 more
TL;DR: Evidence is provided that p38 Map kinase (MAPK) pathway is activated leading to increased upregulation of mixed lineage kinase 3, MKK3/6, MSK1, and Mapkapk2, upon treatment of BCR/ABL expressing cells with dasatinib, including cells expressing various imatinib-resistant mutants, except for T315I.
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Reduced expression of hMSH2 protein is correlated to poor survival for soft tissue sarcoma patients.
Helge Taubert,Frank Bartel,Frank Bartel,Matthias Kappler,Katja Schuster,Axel Meye,Christine Lautenschläger,Barbara Thamm-Mücke,Matthias Bache,Hannelore Schmidt,Hans-Jürgen Holzhausen,Peter Würl +11 more
TL;DR: Although the protein expression of the two main components of DNA mismatch repair, hMSH2 and hMLH1, has been described in soft tissue sarcoma (STS) patients, its prognostic impact is yet to be determined.
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MDM2 splice variants predominantly localize to the nucleoplasm mediated by a COOH-terminal nuclear localization signal.
TL;DR: Nuclear localization signals responsible for the nucleoplasmic distribution ofMDM2 splice variants have been characterized and colocalization and interaction of MDM2-A and MDM1-B with full-length MDM 2 in the nucleus have important physiologic consequences, for example, deregulation of p53 activity.
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