Kathy Ton
6 Papers
Kathy Ton is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 5 publications.
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Papers
A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection
TL;DR: Integrase strand transfer inhibitors (INSTIs) have improved the treatment of human immunodeficiency virus (HIV) by improving the genetic barrier to resistance, limited drugdrug interactions, excellent rates of virologic suppression, and favorable tolerability as mentioned in this paper .
Localized microglia dysregulation impairs central nervous system myelination in development
Rebecca K. Holloway,Liang Zhang,Irene Molina-Gonzalez,Kathy Ton,James A. R. Nicoll,James P. Boardman,Yan Liang,Anna Williams,Veronique E. Miron +8 more
TL;DR: In this article , the authors used digital spatial transcriptomics of a rare bank of human developing white matter to uncover that a localized dysregulated innate immune response is associated with impeded myelination.
Abstract 4709: Spatial whole transcriptome profiling of human normal liver and HCC uncovers unique insights into metabolic zonation
Yang Xiang,Nan Wang,Xia Li,Kathy Ton,Liang Zhang,Charlie Glaser,Zhiyong Ding,Joseph M. Beechem,Andrew Nam +8 more
TL;DR: Liang et al. as mentioned in this paper used GeoMx with the WTA panel to resolve functional units within FFPE tissues in situ and reported the spatial analysis of whole transcriptomes across three micro-dissected zones (pericentral zone 3, intermediate zone 2 and periportal zone 1).
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Abstract 5432: Validation of spatial gene expression patterns predicted by deep convolutional neural networks from breast cancer histopathology images
Kathy Ton,Yinxi Wang,Liuliu Pan,Kimmo Kartasalo,Balazs Acs,Philippe Weitz,Liang Zhang,Yang Xiang,Johan Hartman,Christer Larsson,Pekka Ruusuvuori,Joseph M. Beechem,Mattias Rantalainen +12 more
TL;DR: Ton et al. as discussed by the authors used the GeoMx platform to predict gene expression patterns from whole-slide histopathology images in breast cancer using deep convolutional neural networks.
951 Spatial atlases of immunological development within the lymph node
Tyler Hether,Stephanie Zimmerman,Zachary R. Lewis,Shan He,Liang Zhang,Kathy Ton,Liuliu Pan,Wei Yang,Stefan J. Phelan,Charlie Glaser,Andrew Nam,Emily Brown,Michael Patrick,Gary K. Geiss,S. Church,Michael Rhodes,Yan Liang,Jason Reeves,Joseph M. Beechem +18 more
- 01 Nov 2022
TL;DR: In this article , the authors used a semi-supervised clustering algorithm to map cells to CosMx from lymph node scRNAseq, which was confirmed with protein profiling with GeoMx.