Katherine Shea
Center for Drug Evaluation and Research
20 Papers
77 Citations
Katherine Shea is an academic researcher from Center for Drug Evaluation and Research. The author has contributed to research in topics: Oxycodone & Ceruletide. The author has an hindex of 8, co-authored 19 publications. Previous affiliations of Katherine Shea include Silver Spring Networks & Food and Drug Administration.
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Papers
BLT-Immune Humanized Mice as a Model for Nivolumab-Induced Immune-Mediated Adverse Events: Comparison of the NOG and NOG-EXL Strains.
James L. Weaver,Leah M Zadrozny,Kathleen L. Gabrielson,Kathleen L. Gabrielson,Kenrick M. Semple,Katherine Shea,Kristina E. Howard +6 more
TL;DR: Findings show that BLT immune humanized mice can demonstrate immune-mediated adverse effects of antiPD1 therapy, and may represent a model that can be used to better understand toxicity of this class of drugs.
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Autophagy in Pancreatic Acinar Cells in Caerulein-treated Mice Immunolocalization of Related Proteins and Their Potential as Markers of Pancreatitis
Leshuai W. Zhang,Jun Zhang,Katherine Shea,Lin Xu,Grainne A. McMahon Tobin,Alan Knapton,Stewart Sharron,Rodney Rouse +7 more
TL;DR: Regulating islet-derived 3 gamma (Reg3γ), a pancreatic acute response protein, was dose-dependently induced in caerulein-treated mice and colocalized with the autophagosomal marker, LC3, which supports Reg3γ as a candidate biomarker for pancreatic injury.
21
Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats.
Karol L. Thompson,Jun Zhang,Sharron Stewart,Barry A. Rosenzweig,Katherine Shea,Daniel J. Mans,Thomas Colatsky +6 more
TL;DR: Serum and urinary di-22:6-BMP levels in rats treated with the PLD-inducing drugs amiodarone and 4,4'-diethylaminoethoxyhexestrol dihydrochloride or the hepatotoxicant acetaminophen showed a higher correlation to a generalized PLD incidence score than did levels in urine, but were unexpectedly elevated in rats with marked levels of APAP-induced liver necrosis.
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Assessment of miniaturized ultrasound-powered implants: an in vivo study.
Jesse Vo,Jesse Vo,Ting Chia Chang,Katherine Shea,Matthew R. Myers,Amin Arbabian,Srikanth Vasudevan +6 more
TL;DR: It is found that it is feasible to power UPI devices wirelessly with US over long-term and the encapsulation of UPIs did not degrade over time and the tissues surrounding the UPI were comparable to both naïve control and US exposed tissues.
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Assessment standards: comparing histopathology, digital image analysis, and stereology for early detection of experimental cisplatin-induced kidney injury in rats.
TL;DR: Semiquantitative evaluation as used in this study was most predictive of urinary Kim-1 values, and receiver operator characteristic (ROC) analyses determined the effect of method on biomarker assessment.
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