Katherine S. Ruth
University of Exeter
81 Papers
1.1K Citations
Katherine S. Ruth is an academic researcher from University of Exeter. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 30, co-authored 65 publications. Previous affiliations of Katherine S. Ruth include Royal Devon and Exeter Hospital.
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Papers
Using human genetics to understand the disease impacts of testosterone in men and women
Katherine S. Ruth,Felix R. Day,Jessica Tyrrell,Deborah J. Thompson,Andrew R. Wood,Anubha Mahajan,Robin N Beaumont,Laura B. L. Wittemans,Laura B. L. Wittemans,Susan Martin,Alexander S Busch,Alexander S Busch,A. Mesut Erzurumluoglu,Benjamin Hollis,Tracy A. O'Mara,Mark I. McCarthy,Claudia Langenberg,Douglas F. Easton,Nicholas J. Wareham,Stephen Burgess,Anna Murray,Ken K. Ong,Ken K. Ong,Timothy M. Frayling,John R. B. Perry +24 more
TL;DR: Genetic analysis of data from over 400,000 participants in the UK Biobank Study shows that circulating testosterone levels have sex-specific implications for cardiometabolic diseases and cancer outcomes and the genetic determinants of testosterone levels are substantially different between sexes.
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Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms.
Samuel E. Jones,Jacqueline M. Lane,Jacqueline M. Lane,Andrew R. Wood,Vincent T. van Hees,Jessica Tyrrell,Robin N Beaumont,Aaron R. Jeffries,Hassan S. Dashti,Hassan S. Dashti,Melvyn Hillsdon,Katherine S. Ruth,Marcus A. Tuke,Hanieh Yaghootkar,Seth A. Sharp,Yingjie Jie,William D. Thompson,Jamie W. Harrison,Amy Dawes,Enda M. Byrne,Henning Tiemeier,Karla V. Allebrandt,Jack Bowden,David W. Ray,Rachel M. Freathy,Anna Murray,Diego R. Mazzotti,Philip R. Gehrman,Debbie A Lawlor,Timothy M. Frayling,Martin K. Rutter,David A. Hinds,Richa Saxena,Richa Saxena,Michael N. Weedon +34 more
TL;DR: It is shown that being a morning person is causally associated with better mental health but does not affect BMI or risk of Type 2 diabetes, and the chronotype loci associate with sleep timing.
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
Felix R. Day,Deborah J. Thompson,Hannes Helgason,Hannes Helgason,Daniel I. Chasman,Hilary K. Finucane,Hilary K. Finucane,Patrick Sulem,Katherine S. Ruth,Sean Whalen,Abhishek Sarkar,Abhishek Sarkar,Eva Albrecht,Elisabeth Altmaier,Marzyeh Amini,Caterina Barbieri,Thibaud Boutin,Archie Campbell,Ellen W. Demerath,Ayush Giri,Chunyan He,Jouke J. Hottenga,Robert Karlsson,Ivana Kolcic,Po-Ru Loh,Po-Ru Loh,Kathryn L. Lunetta,Kathryn L. Lunetta,Massimo Mangino,Massimo Mangino,Brumat Marco,George McMahon,Sarah E. Medland,Ilja M. Nolte,Raymond Noordam,Teresa Nutile,Lavinia Paternoster,Natalia Perjakova,Eleonora Porcu,Lynda M. Rose,Katharina E. Schraut,Ayellet V. Segrè,Albert V. Smith,Lisette Stolk,Alexander Teumer,Irene L. Andrulis,Stefania Bandinelli,Matthias W. Beckmann,Javier Benitez,Sven Bergmann,Sven Bergmann,Murielle Bochud,Eric Boerwinkle,Stig E. Bojesen,Manjeet K. Bolla,Judith S. Brand,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Linda Broer,Thomas Brüning,Julie E. Buring,Harry Campbell,Eulalia Catamo,Stephen J. Chanock,Georgia Chenevix-Trench,Tanguy Corre,Tanguy Corre,Fergus J. Couch,Diana L. Cousminer,Angela Cox,Laura Crisponi,Kamila Czene,George Davey Smith,Eco J. C. de Geus,Renée de Mutsert,Immaculata De Vivo,Joe Dennis,Peter Devilee,Isabel dos-Santos-Silva,Alison M. Dunning,Johan G. Eriksson,Peter A. Fasching,Peter A. Fasching,Lindsay Fernández-Rhodes,Luigi Ferrucci,Dieter Flesch-Janys,Lude Franke,Marike Gabrielson,Ilaria Gandin,Graham G. Giles,Graham G. Giles,Harald Grallert,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Pascal Guénel,Per Hall,Emily Hallberg,Ute Hamann,Tamara B. Harris,Catharina A. Hartman,Gerardo Heiss,Maartje J. Hooning,John L. Hopper,Frank B. Hu,David J. Hunter,M. Arfan Ikram,Hae Kyung Im,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Peter K. Joshi,David Karasik,Manolis Kellis,Manolis Kellis,Zoltán Kutalik,Zoltán Kutalik,Genevieve Lachance,Diether Lambrechts,Claudia Langenberg,Lenore J. Launer,Joop S.E. Laven,Stefania Lenarduzzi,Jingmei Li,Penelope A. Lind,Sara Lindström,Yongmei Liu,Jian'an Luan,Reedik Mägi,Arto Mannermaa,Hamdi Mbarek,Mark I. McCarthy,Christa Meisinger,Thomas Meitinger,Cristina Menni,Andres Metspalu,Kyriaki Michailidou,Kyriaki Michailidou,Lili Milani,Roger L. Milne,Roger L. Milne,Grant W. Montgomery,Anna Marie Mulligan,Mike A. Nalls,Pau Navarro,Heli Nevanlinna,Dale R. Nyholt,Albertine J. Oldehinkel,Tracy A. O'Mara,Sandosh Padmanabhan,Aarno Palotie,Nancy L. Pedersen,Annette Peters,Julian Peto,Paul D.P. Pharoah,Anneli Pouta,Paolo Radice,Iffat Rahman,Susan M. Ring,Antonietta Robino,Frits R. Rosendaal,Igor Rudan,Rico Rueedi,Rico Rueedi,Daniela Ruggiero,Cinzia Sala,Marjanka K. Schmidt,Robert A. Scott,Mitul Shah,Rossella Sorice,Melissa C. Southey,Ulla Sovio,Ulla Sovio,Meir J. Stampfer,Maristella Steri,Konstantin Strauch,Toshiko Tanaka,Emmi Tikkanen,Nicholas J. Timpson,Michela Traglia,Thérèse Truong,Jonathan Tyrer,André G. Uitterlinden,Digna R. Velez Edwards,Veronique Vitart,Uwe Völker,Peter Vollenweider,Qin Wang,Elisabeth Widen,Ko Willems van Dijk,Gonneke Willemsen,Robert Winqvist,Bruce H. R. Wolffenbuttel,Jing Hua Zhao,Magdalena Zoledziewska,Marek Zygmunt,Behrooz Z. Alizadeh,Dorret I. Boomsma,Marina Ciullo,Francesco Cucca,Tõnu Esko,Tõnu Esko,Nora Franceschini,Christian Gieger,Vilmundur Gudnason,Caroline Hayward,Peter Kraft,Debbie A Lawlor,Patrik K. E. Magnusson,Nicholas G. Martin,Dennis O. Mook-Kanamori,Ellen A. Nohr,Ozren Polasek,David J. Porteous,Alkes L. Price,Alkes L. Price,Alkes L. Price,Paul M. Ridker,Harold Snieder,Tim D. Spector,Doris Stöckl,Daniela Toniolo,Sheila Ulivi,Jenny A. Visser,Henry Völzke,Nicholas J. Wareham,James F. Wilson,Amanda B. Spurdle,Unnur Thorsteindottir,Unnur Thorsteindottir,Katherine S. Pollard,Katherine S. Pollard,Douglas F. Easton,Joyce Y. Tung,Jenny Chang-Claude,Jenny Chang-Claude,David A. Hinds,Anna Murray,Joanne M. Murabito,Joanne M. Murabito,Kari Stefansson,Kari Stefansson,Ken K. Ong,John R. B. Perry +244 more
TL;DR: In this article, the authors used 1000 Genomes Project-imputed genotype data in up to ∼370,000 women to identify 389 independent signals (P < 5 × 10-8) for age at menarche, a milestone in female pubertal development.
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Nicole M. Warrington,Robin N Beaumont,Momoko Horikoshi,Felix R. Day,Øyvind Helgeland,Øyvind Helgeland,Øyvind Helgeland,Charles Laurin,Jonas Bacelis,Shouneng Peng,Ke Hao,Bjarke Feenstra,Andrew R. Wood,Anubha Mahajan,Jessica Tyrrell,Jessica Tyrrell,Neil Robertson,N. William Rayner,N. William Rayner,Zhen Qiao,Gunn-Helen Moen,Gunn-Helen Moen,Marc Vaudel,Carmen J. Marsit,Jia Chen,Michael Nodzenski,Theresia M. Schnurr,Mohammad Hadi Zafarmand,Jonathan P. Bradfield,Niels Grarup,Marjolein N. Kooijman,Ruifang Li-Gao,Frank Geller,Tarunveer S. Ahluwalia,Lavinia Paternoster,Rico Rueedi,Rico Rueedi,Ville Huikari,Jouke-Jan Hottenga,Leo-Pekka Lyytikäinen,Alana Cavadino,Alana Cavadino,Sarah Metrustry,Diana L. Cousminer,Diana L. Cousminer,Ying Wu,Elisabeth Thiering,Carol A. Wang,Christian Theil Have,Natalia Vilor-Tejedor,Peter K. Joshi,Jodie N. Painter,Ioanna Ntalla,Ronny Myhre,Niina Pitkänen,Elisabeth M. van Leeuwen,Raimo Joro,Vasiliki Lagou,Vasiliki Lagou,Rebecca C Richmond,Ana Espinosa,Sheila J. Barton,Hazel Inskip,Hazel Inskip,John W. Holloway,Loreto Santa-Marina,Xavier Estivill,Wei Ang,Julie A. Marsh,Christoph Reichetzeder,Letizia Marullo,Berthold Hocher,Kathryn L. Lunetta,Joanne M. Murabito,Caroline L Relton,Manolis Kogevinas,Leda Chatzi,Catherine Allard,Luigi Bouchard,Luigi Bouchard,Marie-France Hivert,Marie-France Hivert,Ge Zhang,Ge Zhang,Louis J. Muglia,Louis J. Muglia,Jani Heikkinen,Camilla Schmidt Morgen,Antoine H. C. van Kampen,Antoine H. C. van Kampen,Barbera D. C. van Schaik,Frank D. Mentch,Claudia Langenberg,Jian'an Luan,Robert A. Scott,Jing Hua Zhao,Gibran Hemani,Susan M. Ring,Amanda J. Bennett,Kyle J. Gaulton,Kyle J. Gaulton,Juan Fernández-Tajes,Natalie R. van Zuydam,Carolina Medina-Gomez,Hugoline G. de Haan,Frits R. Rosendaal,Zoltán Kutalik,Zoltán Kutalik,Pedro Marques-Vidal,Shikta Das,Gonneke Willemsen,Hamdi Mbarek,Martina Müller-Nurasyid,Marie Standl,Emil V. R. Appel,Cilius Esmann Fonvig,Cæcilie Trier,Catharina E. M. van Beijsterveldt,Mario Murcia,Mariona Bustamante,Sílvia Bonàs-Guarch,David M. Hougaard,Josep M. Mercader,Josep M. Mercader,Josep M. Mercader,Allan Linneberg,Katharina E. Schraut,Penelope A. Lind,Sarah E. Medland,Beverley M. Shields,Bridget A. Knight,Jin-Fang Chai,Kalliope Panoutsopoulou,Meike Bartels,Friman Sánchez,Jakob Stokholm,David Torrents,David Torrents,Rebecca K. Vinding,Sara M. Willems,Mustafa Atalay,Bo L. Chawes,Peter Kovacs,Inga Prokopenko,Inga Prokopenko,Marcus A. Tuke,Hanieh Yaghootkar,Katherine S. Ruth,Samuel E. Jones,Po-Ru Loh,Po-Ru Loh,Anna Murray,Michael N. Weedon,Anke Tönjes,Michael Stumvoll,Kim F. Michaelsen,Aino-Maija Eloranta,Timo A. Lakka,Cornelia M. van Duijn,Wieland Kiess,Antje Körner,Harri Niinikoski,Harri Niinikoski,Katja Pahkala,Olli T. Raitakari,Olli T. Raitakari,Bo Jacobsson,Bo Jacobsson,Eleftheria Zeggini,George Dedoussis,Yik Ying Teo,Seang-Mei Saw,Grant W. Montgomery,Harry Campbell,James F. Wilson,Tanja G. M. Vrijkotte,Martine Vrijheid,Eco J. C. de Geus,M. Geoffrey Hayes,Haja N. Kadarmideen,Jens-Christian Holm,Lawrence J. Beilin,Craig E. Pennell,Joachim Heinrich,Linda S. Adair,Judith B. Borja,Karen L. Mohlke,Johan G. Eriksson,Johan G. Eriksson,Elisabeth Widen,Andrew T. Hattersley,Andrew T. Hattersley,Tim D. Spector,Mika Kähönen,Jorma Viikari,Jorma Viikari,Terho Lehtimäki,Dorret I. Boomsma,Sylvain Sebert,Peter Vollenweider,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Hans Bisgaard,Klaus Bønnelykke,Jeff Murray,Mads Melbye,Ellen A. Nohr,Dennis O. Mook-Kanamori,Fernando Rivadeneira,Albert Hofman,Janine F. Felix,Vincent W. V. Jaddoe,Torben Hansen,Charlotta Pisinger,Allan Vaag,Oluf Pedersen,André G. Uitterlinden,Marjo-Riitta Järvelin,Christine Power,Elina Hyppönen,Elina Hyppönen,Denise M. Scholtens,William L. Lowe,George Davey Smith,Nicholas J. Timpson,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Nicholas J. Wareham,Hakon Hakonarson,Hakon Hakonarson,Struan F.A. Grant,Timothy M. Frayling,Debbie A Lawlor,Pål R. Njølstad,Pål R. Njølstad,Stefan Johansson,Stefan Johansson,Ken K. Ong,Mark I. McCarthy,Mark I. McCarthy,John R. B. Perry,David M. Evans,David M. Evans,Rachel M. Freathy,Rachel M. Freathy +245 more
TL;DR: An expanded GWAS of birth weight and subsequent analysis using structural equation modeling and Mendelian randomization decomposes maternal and fetal genetic contributions and causal links between birth weight, blood pressure and glycemic traits.
Genome-wide associations for birth weight and correlations with adult disease
Momoko Horikoshi,Robin N Beaumont,Felix R. Day,Nicole M. Warrington,Nicole M. Warrington,Marjolein N. Kooijman,Juan Fernández-Tajes,Bjarke Feenstra,Natalie R. van Zuydam,Kyle J. Gaulton,Kyle J. Gaulton,Niels Grarup,Jonathan P. Bradfield,David P. Strachan,Ruifang Li-Gao,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Eskil Kreiner,Rico Rueedi,Rico Rueedi,Leo-Pekka Lyytikäinen,Diana L. Cousminer,Diana L. Cousminer,Diana L. Cousminer,Ying Wu,Elisabeth Thiering,Carol A. Wang,Christian Theil Have,Jouke-Jan Hottenga,Natalia Vilor-Tejedor,Peter K. Joshi,Eileen Tai-Hui Boh,Ioanna Ntalla,Ioanna Ntalla,Niina Pitkänen,Anubha Mahajan,Elisabeth M. van Leeuwen,Raimo Joro,Vasiliki Lagou,Vasiliki Lagou,Michael Nodzenski,Louise A. Diver,Krina T. Zondervan,Mariona Bustamante,Pedro Marques-Vidal,Josep M. Mercader,Amanda J. Bennett,Nilufer Rahmioglu,Dale R. Nyholt,Ronald C.W. Ma,Claudia H. T. Tam,Wing Hung Tam,Santhi K. Ganesh,Frank J.A. van Rooij,Samuel E. Jones,Po-Ru Loh,Katherine S. Ruth,Marcus A. Tuke,Jessica Tyrrell,Andrew R. Wood,Hanieh Yaghootkar,Denise M. Scholtens,Lavinia Paternoster,Inga Prokopenko,Inga Prokopenko,Peter Kovacs,Mustafa Atalay,Sara M. Willems,Kalliope Panoutsopoulou,Xu Wang,Lisbeth Carstensen,Frank Geller,Katharina E. Schraut,Mario Murcia,Catharina E. M. van Beijsterveldt,Gonneke Willemsen,Emil V. R. Appel,Cilius Esmann Fonvig,Cæcilie Trier,Carla M. T. Tiesler,Marie Standl,Zoltán Kutalik,Zoltán Kutalik,Sílvia Bonàs-Guarch,David M. Hougaard,Friman Sánchez,David Torrents,Johannes Waage,Mads V. Hollegaard,Hugoline G. de Haan,Frits R. Rosendaal,Carolina Medina-Gomez,Susan M. Ring,Gibran Hemani,George McMahon,Neil R. Robertson,Christopher J. Groves,Claudia Langenberg,Jian'an Luan,Robert A. Scott,Jing Hua Zhao,Frank D. Mentch,Scott M. MacKenzie,Rebecca M. Reynolds,William L. Lowe,Anke Tönjes,Michael Stumvoll,Virpi Lindi,Timo A. Lakka,Cornelia M. van Duijn,Wieland Kiess,Antje Körner,Thorkild I. A. Sørensen,Harri Niinikoski,Katja Pahkala,Olli T. Raitakari,Eleftheria Zeggini,George Dedoussis,Yik Ying Teo,Seang-Mei Saw,Mads Melbye,Mads Melbye,Mads Melbye,Harry Campbell,James F. Wilson,Martine Vrijheid,Eco J. C. de Geus,Eco J. C. de Geus,Dorret I. Boomsma,Haja N. Kadarmideen,Jens-Christian Holm,Torben Hansen,Sylvain Sebert,Sylvain Sebert,Andrew T. Hattersley,Lawrence J. Beilin,John P. Newnham,Craig E. Pennell,Joachim Heinrich,Linda S. Adair,Judith B. Borja,Karen L. Mohlke,Johan G. Eriksson,Johan G. Eriksson,Elisabeth Widen,Mika Kähönen,Jorma Viikari,Terho Lehtimäki,Peter Vollenweider,Klaus Bønnelykke,Hans Bisgaard,Dennis O. Mook-Kanamori,Albert Hofman,Fernando Rivadeneira,André G. Uitterlinden,Charlotta Pisinger,Oluf Pedersen,Christine Power,Elina Hyppönen,Elina Hyppönen,Nicholas J. Wareham,Hakon Hakonarson,Eleanor Davies,Brian R. Walker,Vincent W. V. Jaddoe,Marjo-Riitta Järvelin,Struan F.A. Grant,Allan Vaag,Allan Vaag,Debbie A Lawlor,Timothy M. Frayling,George Davey Smith,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Ken K. Ong,Janine F. Felix,Nicholas J. Timpson,John R. B. Perry,David M. Evans,David M. Evans,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Rachel M. Freathy,Rachel M. Freathy +185 more
TL;DR: In this paper, the authors performed a meta-analysis of birth weight in 153,781 individuals, identifying 60 loci where fetal genotype was associated with birth weight (P < 5.5×10−8).