Katherine E. Havranek
University of Georgia
5 Papers
Katherine E. Havranek is an academic researcher from University of Georgia. The author has contributed to research in topics: Virus & Biology. The author has an hindex of 1, co-authored 3 publications.
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Papers
SARS-CoV-2 Spike Alterations Enhance Pseudoparticle Titers and Replication-Competent VSV-SARS-CoV-2 Virus.
Katherine E. Havranek,Ariana R Jimenez,Marissa Danielle Acciani,Maria Fernanda Lay Mendoza,Judith Mary Reyes Ballista,Darren Diaz,Melinda A. Brindley +6 more
TL;DR: This study produced pseudotyped VSV particles with multiple modifications to S, including truncation, mutation, and tagging strategies, to determine which modifications of the S protein optimize cell surface expression, incorporation into pseudotypesed particles, and pseudoparticle entry.
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Ebola Virus Requires Phosphatidylserine Scrambling Activity for Efficient Budding and Optimal Infectivity.
Marissa Danielle Acciani,Maria Fernanda Lay Mendoza,Katherine E. Havranek,Avery M. Duncan,Hersha Iyer,Olivia L. Linn,Melinda A. Brindley +6 more
TL;DR: In this paper, two scramblases, transmembrane protein 16F (TM16F) and Xk-related protein 8 (XKR8), were investigated as mediators of cellular and viral envelope surface PS levels during the replication of recombinant vesicular stomatitis virus containing its native glycoprotein (rVSV/G) or the EBOV glycopprotein (rVV/EBOV-GP).
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Ebola virus requires phosphatidylserine scrambling activity for efficient budding and optimal infectivity
Marissa Danielle Acciani,Maria F. Lay-Mendoza,Katherine E. Havranek,Avery M. Duncan,Hersha Iyer,Olivia L. Linn,Melinda A. Brindley +6 more
TL;DR: The role of two scramblases, TMEM16F and XKR8, are investigated as possible mediators of cellular and viral envelope surface PS levels during recombinant vesicular stomatitis virus (VSV) replication and EBOV virus-like particle (VLP) production, finding that rVSV/EBOV-GP and E BOV VLPs produced in X KR8 knockout cells contain two- to threefold less PS in their outer leaflets.
Chikungunya virus entry and infectivity is primarily facilitated through cell line dependent attachment factors in mammalian and mosquito cells
Judith Mary Reyes Ballista,Kerri L. Miazgowicz,Marissa Danielle Acciani,Ariana R Jimenez,Ryan S. Belloli,Katherine E. Havranek,Melinda A. Brindley +6 more
TL;DR: In this paper , the importance of particular binding factors during chikungunya infection is highly cell line dependent and none of these factors are necessary for CHIKV entry, suggesting additional host factors are involved.
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Phosphatidylserine within the Viral Membrane Enhances Chikungunya Virus Infectivity in a Cell-type Dependent Manner
Kerri L. Miazgowicz,Judith Mary Reyes Ballista,Marissa Danielle Acciani,Ariana R Jimenez,Ryan S. Belloli,Avery M. Duncan,Katherine E. Havranek,Melinda A. Brindley +7 more
TL;DR: This study produced viral particles with discrete amounts of exposed PS on the virion envelope by exploiting the cellular distribution of phospholipids at the plasma membrane and observed that higher levels of externalized phosphatidylserine in the viral lipid bilayer correlated with enhanced CHIKV infectivity in mammalian cells abundant with PS receptors and lacking alternative attachment factors.
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