Kate Williamson

TL;DR: In this paper , the authors track lymphocyte clones and their progenies from induced antigen signals to investigate the maintenance of localised T cell tolerance in tumour immunity and reveal how Tregs differentiate to a reversible, tolerance inducing state within the tumour, and recirculate, while CD8+ T cells failing to recurulate, differentiate to an increasingly exhausted, tolerant state in the tumours.